摘要
Abstract
Objective To explore the efficacy and safety of different doses of mifepristone in the treatment of uterine fibroids. Methods 90 cases with uterine fibroids from April 2012 to August 2013 were randomly divided into observation group and control group. The two groups were given mifepristone tablets for treatment, the dosage of the observation group was 12. 5 mg, and the control group was 25 mg. After the end of treatment, the efficiency, fibroid volume before and after uterine, the patients' adverse reaction rates were compared and analyzed. Results The total effective rate was 84. 44% in the control group, which was significantly lower than 95. 56% in the obser-vation group;( U = 2. 154 6,P = 0. 031 2); the uterine fibroid volume in the observation group before the treatment was (45. 18 ± 12. 12 ) mm, after treatment was (30. 15 ± 9. 55) mm, and the uterine fibroid volume in the control group before the treatment was (46. 13 ± 12. 21) mm, after treatment was (30. 98 ± 9. 57) mm, which had significantly reduced compared with before treatment( P ﹤0. 05); after treatment, the two groups had no significant difference in the uterine fibroid volume( P ﹥ 0. 05); the total adverse reaction rate in the control group was 26. 27% (12 cases), which was significantly higher than 6. 67% (3 cases) in the observation group( P ﹤0. 05). Conclusion The best dosage of mifepristone is 12. 5 mg per day. The treatment is safe, effective, with few adverse reactions and is economic and feasible, which is worthy of clinical promotion.关键词
米非司酮/子宫肌瘤/临床疗效/剂量Key words
mifepristone/uterine fibroid/clinical efficacy/dosage分类
医药卫生
