摘要
Abstract
Objective To evaluate the protective effect of creatine phosphate sodium on chemotherapy - induced myocardial injury by ultrasonic cardiogram. Methods 98 breast cancer patients after radical continue chemotherapy from January 2011 to July 2015 were randomly divided into control and treatment groups,49 cases in each group. The two groups received different conventional chemotherapy program on an individual basis. The control group received intravenous vitamin C at the beginning of the chemotherapy, once daily, for continuous 7 d; the observation group received intravenous creatine phosphate sodium, 2 times a day for 7 d. The two groups were syn-chronized with the course of chemotherapy treatment. The incidence of abnormal electrocardiogram after treatment, and the ultrasonic car-diogram before and after treatment were observed; the myocardial damage related biochemical indicators were evaluated before and after treatment; the occurrence of adverse reactions were recorded. Results After treatment, the levels of Q - Tcd of the patients were in-creased than before treatment, but the observation group increased to a lesser extent than the control group, the differences were statisti-cally significant( P ﹤ 0. 05); the ST - T segment change, QRS wave depression and QT prolongation incurred in both groups after the treatment, and the incidence rate of ECG change in the observation group were not as high as the control group( P ﹤ 0. 05) . After treatment, the LVEF, left ventricular Tei, LVED, E / A by ultrasonic cardiogram all changed in the two groups, and the fluctuations of these changes in the observation group were smaller than the control group after treatment, the differences were statistically significant ( P ﹤ 0. 05). The levels of Pro - BNP, CK - MB, cTnI indicators were increased in the two groups, but the observation group increased to a lesser extent than the control group, the differences were statistically significant( P ﹤ 0. 05 ) . The overall incidence rates of adverse reactions in the two groups were equal, and the difference was not statistically significant( P ﹥ 0. 05). Conclusion Ultrasonic cardiogram is an effective means of detecting myocardial damage induced by chemotherapy. Creatine sodium phosphate has a certain effect on chemotherapy - induced myocardial damage, can significantly reduce cardiac dysfunction indicators without increasing the incidence rate of adverse reactions, which is suitable for clinical promotion.关键词
磷酸肌酸钠/化学治疗/超声心动图/心肌损伤Key words
creatine phosphate sodium/chemotherapy/echocardiography/myocardial injury分类
医药卫生
