摘要
Abstract
Objective To investigate the effects of Salvianolate Injection on inflammatory response and oxidative stress in patients with Acute exacerbated chronic obstructive pulmonary disease ( AECOPD ) . Methods 130 patients with AECOPD who were hospitalized in the department of respiration in the hospital from February 2013 to October 2015 were selected and divided into the control group and the treatment group,65 cases in each group. The two groups were given routine therapies,while on this basis 200 mg Salvianolate Injection was added to the treatment group by intravenous dripping,once daily for totally 14 d. The changes of 8-isoPG,IL-18,IL-1β,the pulmonary functions and CAT scores before and after treatment were evaluated in the two groups,and were compared with those of 65 healthy controls. Results Before treatment,the differences in the FEV1%,FEV1/FVC,CAT volume table score,and serum 8-isoPG, IL-18,IL-1β levels in the two groups were not statistically significant( P > 0. 05),but FEV1%,FEV1/FVC and serum 8-isoPG, IL-18,IL-1β levels were significantly higher than the normal control group. Compared with before treatment,FEV1% and FEV1/FVC in the two groups increased significantly after treatment,CAT scores and serum 8-isoPG,IL-18,IL-1β levels decreased significantly ( P < 0. 01 or P < 0. 05). After treatment,the serum levels of 8-isoPG,IL-18,IL-1β and CAT scores in the treatment group were significantly different from the control group ( P < 0. 05). Conclusion Salvianolate Injection can improve the lung function index in patients with AECOPD,reduce CAT scale scores,improve the quality of life. It is safe and effective without severe adverse reactions, which is worthy of clinical promotion.关键词
丹参多酚酸盐注射液/慢性阻塞性肺疾病急性加重/炎性反应/氧化应激Key words
Salvianolate Injection/acute exacerbations chronic obstructive pulmonary disease/inflammatory reaction/oxidative stress分类
医药卫生
