摘要
Abstract
Objective To explore the efficacy and safety of low dose glucocorticoid ( GC ) combined with N-acetylcysteine ( NAC ) in the treatment of idiopathic pulmonary fibrosis ( IPF ) . Methods 72 patients diagnosed with IPF from May 2013 to April 2015 were ran-domly divided into the control group and the observation grou, 36 cases in each group. The control group was given conventional dose ( equal to or more than 80 mg ) methylprednisolone combined with NAC treatment;the observation group was given treatment of small dose (< 80 mg/d ) methylprednisolone combined with NAC treatment. Pulmonary function indicators [ forced vital capacity/expected value ( FVC%pred ) , the volume of carbon monoxide diffusing capacity per unit ( DLCO/VA%pred ) and forced expiratory volume/esti-mated value ( FEV1%pred ) ] , Brog dyspnea score, CAT quality of life score and exercise endurance test and adverse reactions occurred were recorded and compared in the two groups before and after the treatment. Results The difference of FVC%pred, DLCO/VA%pred, FEV1%pred, Brog score, CAT score and exercise tolerance test results in the two groups before treatment not statistically significant ( P > 0. 05 ); after treatment, FVC%pred, DLCO/VA%pred, FEV1%pred were ( 73. 4 ± 9. 5 ) , ( 81. 2 ± 12. 8 ) and ( 64. 6 ± 14. 8 ) in the observation group, which were higher than ( 67. 1 ± 9. 2 ) , ( 72. 5 ± 8. 3 ) and ( 61. 1 ± 10. 4 ) in the control group ( P < 0. 05 ); after 3 months of treatment, Brog dyspnea scores in observation group were significantly lower than the control group, while CAT score and ex-ercise tolerance test scores were significantly higher ( P < 0. 05 ); the difference of adverse reactions incidence such as high blood pressure, low back pain, elevated blood glucose was not statistically significant ( P > 0. 05 ) . Conclusion Low dose of GC combined with NAC in treatment of IPF can significantly improve the patients′ lung function and quality of life, which is worthy of clinical promotior.关键词
糖皮质激素/N-乙酰半胱氨酸/特发性肺纤维化/临床疗效Key words
glucocorticoid/N-acetylcysteine/idiopathic pulmonary fibrosis/clinical efficacy分类
医药卫生
