摘要
Abstract
Objective To investigate the clinical efficacy of anti-thyroid drugs ( ATD ) treatment for primary hyperthyroidism ( PHT ) and the ultrasonic evaluation of it by color Doppler ultrasound detection. Methods 60 cases of patients with PHT from January 2014 to January 2015 were evenly divided into the echo type group ( group A ) and the uneven echo model ( group B ) , 30 cases in each group. In addition, 35 cases of healthy volunteers were chosen from medical center, which was treated as control group. The parameters of thyroid gland and kinetic parameters of the upper lobe thyroid artery were tested with color ultrasonic diagnostic instrument:diameter of upper lobe thyroid artery ( D ) , total gland volume ( V ) , systolic peak velocity ( vmax ) , end diastolic velocity ( vmin ) , resistance index ( RI ) and blood flow ( Q ) . The serum free thyroid hormone T3, T4 ( FT3, FT4 ) , thyroid stimulating hormone ( TSH ) and TSH receptor antibody ( TRAb ) of patients were detected via radioimmunoassay respectively before and after treatment 1 year. The complications of patients af-ter treatment was statistical analyzed. Results The total effective rate of ATD treatment on patients with PHT was 68. 33%( 41/60 ) , in which total effective rate of group A was 76. 67% ( 23/30 ) , which was significantly higher than 60. 00%( 18/30 ) of group B, and the difference was statistically significant ( P < 0. 01 );compared with before treatment, the serum of indexes of two groups of patients after treatment were significantly improved, and the improvement of patients of group A was superior to those of group B, which the differ-ences were statistically significant ( P < 0. 05 );the V, vmax, vmin and Q of patients with PHT after treatment were significantly lower than before treatment, and RI was significantly higher than before the treatment, which the differences were statistically significant ( P <0. 05 );except for RI, various targets of patients with PHT were obviously better than the control group, in addition, improvement of each index of patients in group A after treatment was significantly better than group B, the differences were statistically significant ( P <0. 05 ) . The difference between the incidence of complications of patients in two groups had no statistical significance ( P > 0. 05 ) . Conclusion ATD can effectively treat patients with even the echo type of PHT, which effectively improve the thyroid related indica-tors. Hemodynamic parameters of patients with PHT were evaluated by color Doppler ultrasound, which provides the theoretical foundation for clinical treatment.关键词
超声/抗甲状腺药物/原发性甲状腺功能亢进症/临床疗效Key words
ultrasound/anti-thyroid drugs/primary hyperthyroidism/clinical efficacy分类
医药卫生
