中国药业2016，Vol.25Issue(13)：92-94,3.
25－羟维生素D、甲状旁腺激素与2型糖尿病视网膜病变的相关性研究
Correlation Study of 25-Hydroxy Vitamin D, Parathyroid Hormone and Type 2 Diabetes Mellitus Retinopathy
摘要
Abstract
Objective To explore the relationship of 25-hydroxy vitamin D, parathyroid hormone and type 2 diabetic retinopathy ( DR ) , and to conduct the correlation analysis to provide reference for the DR prevention and clinical treatment. Methods 200 patients with type 2 diabetes who were treated in the hospital were divided according to fundus fluorescein angiography in phases into: no diabetic retinopathy ( NDR ) group and background retinopathy ( NPDR ) group, the early proliferative retinopathy ( EPDR ) group and proliferative retinopathy ( PDR ) , 50 cases in each group. Another 50 cases with nondiabetic subjects were selected as the control group. The 25 ( OH ) D, glycosylated hemoglobin ( HbA1C ) , fasting blood glucose ( FBG ) , high density lipoprotein ( HDL ) , low density lipoprotein ( LDL ) , serum total calcium and PTH levels of all subjects were detected with an empty stomach in the morning, and the 25 ( OH ) D levels and a straight line of all biochemical markers were analyzed. Results The HbA1C, and LDH, and FBG levels in the 4 group type 2 diabetes groups were significantly higher than the control group ( P < 0. 05 );the HDH levels of the 4 group type 2 diabetes group were significantly lower than the control group ( P < 0. 05 );the serum total calcium level and 25 ( OH ) D level of the control group had no significant differences with the NDR group ( P > 0. 05 ) but were significantly lower than patients with retinal lesions of type 2 diabetes ( P < 0. 05 );the PTH levels of the 5 groups of subjects had no significant difference ( P > 0. 05 );the levels of HbA1C, and FBG and 25 ( OH ) d was negatively correlated ( P < 0. 05 ) and total calcium in serum 25 ( OH ) D were positively correlated ( P < 0. 05 ); the levels of HDL, and LDL, and PTH 25 ( OH ) D were not related ( P > 0. 05 ) . Conclusion The severity of retinopathy in type 2 diabetes mellitus and 25 ( OH ) D is closely related, but PTH and 25 ( OH ) D have no significant correlation;25 ( OH ) D can in a certain degree predict the severity of diabetic retinopathy.关键词
25-羟维生素D/甲状旁腺激素/糖尿病视网膜病变/相关性Key words
25-hydroxy vitamin D/parathyroid hormone/type 2 diabetic retinopathy/correlation分类
基础医学引用本文复制引用
韩改玲..25－羟维生素D、甲状旁腺激素与2型糖尿病视网膜病变的相关性研究[J].中国药业,2016,25(13):92-94,3.基金项目
河北省秦皇岛市科学技术研究与发展计划，项目编号2012023A084。 （）
