肿瘤药学2016，Vol.6Issue(3)：161-165,5.DOI:10.3969/j.issn.2095-1264.2016.03.01
MCP-1/CCR2信号轴在消化系统肿瘤发生发展中的研究进展
Research Progress on the Role of MCP-1/CCR2 Signaling Axis in the Development of Gastrointestinal Tumors
摘要
Abstract
Monocyte chemoattractant protein-1 (MCP-1) / CC chemokine receptor 2 (CCR2) signaling axis is defined as a coupled molecule that was made up by the interaction between chemokine MCP-1 and its specific receptor CCR2 and closely related to the intercellular information transmission and cell migration. MCP-1/CCR2 signal axis is expressed in tu-mor cells and a variety of cells in tumor microenvironment. It plays an important role in the development of tumor. Its role in the development of digestive system neoplasm received increasing attention from researchers in the world. The mechanisms involved the recruitment and polarization of tumor-associated macrophages, angiogenesis and abnormal immune response, etc. It would provide new ideas for the prevention and treatment of gastrointestinal tumors. The present article summarized the recent advances in the role of MCP-1/CCR2 signaling axis in the development of gastrointestinal tumors, and outlined the future prospect.关键词
消化系统肿瘤/MCP-1/CCR2/肿瘤相关巨噬细胞/新生血管生成Key words
Gastrointestinal tumors/MCP-1/CCR2/Tumor-associated macrophages/Angiogenesis分类
医药卫生引用本文复制引用
刘天宇,曹海龙,王邦茂..MCP-1/CCR2信号轴在消化系统肿瘤发生发展中的研究进展[J].肿瘤药学,2016,6(3):161-165,5.基金项目
国家自然科学基金（81300272，81570478）。 （）
