肿瘤药学2016，Vol.6Issue(3)：166-172,7.DOI:10.3969/j.issn.2095-1264.2016.03.02
受体酪氨酸激酶 ROS 在肿瘤中作用的研究进展
Research Progress on the Roles of Receptor Tyrosine Kinase ROS in Tumor
谢蒙蒙 1李莹 1文周 1吴晓波 2程泽能1
作者信息
- 1. 中南大学药学院，湖南 长沙，410013
- 2. 中南大学湘雅三医院普外科，湖南 长沙，410013
- 折叠
摘要
Abstract
As the largest category of enzyme-linked receptors, receptor tyrosine kinases (RTKs) can phosphorylate the tyrosine residues of target protein, through working both as a kind of receptor and an enzyme. The mediated signal transduc-tion of RTKs is closely related to the tumor development, so that the tumor cells can be damaged by blocking tyrosine kinase signaling to achieve the purpose of antitumor. Reactive oxygen species (ROS) was found in UR2 carcinogenic product more than 30 years ago. It was found that it may cause the activation of tyrosine kinase activity. This paper gives an overview of the role of ROS in gene regulation, expression in the diseases and ROS-mediated signal transduction in the process of cell proliferation and cell survival signaling. This review may offer new intervention targets and arouse thoughts for the treatment of cancers.关键词
受体酪氨酸激酶/ROS/肿瘤/信号转导Key words
Receptor tyrosine kinases/ROS/Cancer/Signal transduction分类
医药卫生引用本文复制引用
谢蒙蒙,李莹,文周,吴晓波,程泽能..受体酪氨酸激酶 ROS 在肿瘤中作用的研究进展[J].肿瘤药学,2016,6(3):166-172,7.
