肿瘤药学2016，Vol.6Issue(3)：178-181,4.DOI:10.3969/j.issn.2095-1264.2016.03.04
BRAF V600E 和 RAS 基因突变与甲状腺癌远处转移及预后关系的研究进展
Research Progress on the Relationships of BRAF V600E and RAS Gene Mutation with Distant Metastasis and Prognosis of Thyroid Carcinoma
周瑞瑜 1罗以1
作者信息
- 1. 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院 头颈肿瘤内科，湖南 长沙，410013
- 折叠
摘要
Abstract
BRAF and RAS mutation are two of the most frequent mutated genes in thyroid carcinoma. BRAF gene plays an important role in the RET/RAS/BRAF/MAPK signal pathway. Its product can transfer the signal on the cell membrane. However, RAS gene can mediate the signal channel of tyrosine kinase - G protein coupled receptor -MAPK/PI3K-AKT. Both of them are capable of regulation the differentiation, proliferation and apoptosis of cells. When the genes get mutated, pathways from downstream will be continually activated, which will promote the development of tumor. In this paper, we re-viewed the latest researches on the relationship of BRAF or RAS gene mutation with the distant metastasis and prognosis of thyroid carcinoma.关键词
甲状腺癌/远处转移/BRAF V600E 突变/RAS 突变/预后Key words
Thyroid carcinoma/Distant metastasis/BRAF V600E mutation/RAS mutation/Prognosis分类
医药卫生引用本文复制引用
周瑞瑜,罗以..BRAF V600E 和 RAS 基因突变与甲状腺癌远处转移及预后关系的研究进展[J].肿瘤药学,2016,6(3):178-181,4.
