肿瘤药学2016，Vol.6Issue(3)：185-188,4.DOI:10.3969/j.issn.2095-1264.2016.03.06
甘氨双唑钠放射增敏联合术前同步放化疗治疗Ⅱ、Ⅲ期直肠癌的临床疗效研究
Observation on Clinical Efficacy of Preoperative Chemo-radiotherapy Combined with Sodium Glycididazole on Rectal Cancer at Stage Ⅱ/Ⅲ
摘要
Abstract
Objective To investigate the clinical efficacy and safety of Sodium glycididazole combined with preoperative chemoradio-therapy on rectal cancer at stage Ⅱ/Ⅲ. Methods A total of 49 patients were divided into the Sodium glycididazole group (group A, 19 pa-tients) and the control group without Sodium glycididazole (group B, 30 patients). The dose of Sodium glycididazole was 800 mg·m-2, which was used one hour before radiotherapy every Monday, Wednesday and Friday. The prescription dose of radiotherapy was 46-50 Gy,1.8-2.0 Gy/fraction, 5 times per week. The modality of concurrent chemotherapy was Fluorouracile/Calcium folinate or Capecitabine. After treat-ment, we observed and compared the clinical efficacy and adverse effects of the two groups. The grades of pathologic response were used to assess the clinical efficacy. Results After treatment, there were 7 cases (14.29%) of complete response (CR, ypT0N0), 16 cases (32.65%) of intermediate response (IR, ypT1T2N0) and 26 cases (53.06%) of poor response (PR, ypT3T4 or N+). The rates of patients with CR, IR, and PR were respectively 10.53%, 31.58% and 57.89% in group A but 16.67%, 33.00% and 50.00% in group B. The differences of grades of pathologic response between the two groups were insignificant (P=0.921). There was also no significant difference in adverse effect between the two groups (P>0.05). Conclusions Sodium glycididazole can not improve the degree of pathologic response of rectal cancer at stage Ⅱ/Ⅲ. We do not recommend Sodium glycididazole as radio sensitizer in combination with preoperative chemoradiotherapy to treat rectal can-cer at present.关键词
直肠癌/甘氨双唑钠/同步放化疗Key words
Rectal cancer/Sodium glycididazole/Concurrent chemoradiotherapy引用本文复制引用
刘科,刘媛媛,李金娇,邓俊,吴峥,朱苏雨..甘氨双唑钠放射增敏联合术前同步放化疗治疗Ⅱ、Ⅲ期直肠癌的临床疗效研究[J].肿瘤药学,2016,6(3):185-188,4.基金项目
湖南省肿瘤医院生物靶向调强放射研究室基金。 （）
