肿瘤药学2016，Vol.6Issue(3)：203-207,5.DOI:10.3969/j.issn.2095-1264.2016.03.10
紫杉醇脂质体联合奈达铂治疗中晚期宫颈癌放疗患者的临床疗效
Clinical Efficacy of Paclitaxel Liposomal and Nedaplatin on Advanced Cervical Cancer Patients Treated with Radiotherapy
高薇薇 1姚微 1叶霖1
作者信息
- 1. 南通大学附属医院妇产科，江苏 南通，226000
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy of advanced cervical cancer patients treated by radiotherapy combined with paclitaxel liposomal platinum nedaplatin. Methods In this study, 69 patients with advanced cervical cancer were selected from our hospital during January 2012 and June 2014. They were randomly divided into the observation group (35 cases) and the control group (34 cases). Patients in the control group were treated by radiation therapy, while those in the ob-servation group were treated by combination of paclitaxel liposome with nedaplatin chemotherapy on the basis of radiotherapy. Patients in the two groups had 21d as a treatment cycle, and all had continuous 3 cycles of treatment. Effects of treatment, QOL and Karnofsky score before and after treatment, serum squamous-cell carcinoma (SCC) and tumor specific growth factor (TSGF) levels, and drug toxicity were compared between the two groups. Results The response rate (RR) of the observation group (71.43%) was significantly higher than that of the control group (44.12%) (P<0.05). After treatment, the QOL and Karnofsky score in both groups increased significantly (P<0.05). And the observation group had higher QOL and Karnofsky score than that of the control group after treatment (P<0.05). There was no statistical difference in the incidence of adverse reaction be-tween the two groups (P>0.05). Serum SCC and TSGF levels in the two groups decreased significantly after treatment (P<0.05), and the SCC and TSGF levels were lower in the observation group than the control group (P<0.05). Conclusion Paclitaxel liposome combined with nedaplatin had significant effects on advanced cervical cancer patients who received radiotherapy si-multaneously. Its role may be associated with the decreasing of serum SCC and TSGF levels.关键词
紫杉醇脂质体/奈达铂/中晚期宫颈癌/放疗/疗效Key words
Paclitaxel liposome/Nedaplatin/Advanced cervical cancer/Radiotherapy/Efficacy分类
医药卫生引用本文复制引用
高薇薇,姚微,叶霖..紫杉醇脂质体联合奈达铂治疗中晚期宫颈癌放疗患者的临床疗效[J].肿瘤药学,2016,6(3):203-207,5.
