安徽农业科学2016，Vol.44Issue(16)：164-166,3.
副猪嗜血杆菌国内流行血清型对小鼠外周血淋巴细胞·细胞因子及免疫球蛋白水平的影响
Level of Peripheral Blood Lymphocytes, Cytokines and Immunoglobulins in Mice Infected with the Epidemic Serotypes Haemophilus parasuis in China
摘要
Abstract
Objective] To comparatively study on level of peripheral blood lymphocytes, cytokines, and immunoglobulins ( Ig) in mice infec-ted with the epidemic serotypes Haemophilus parasuis in China. [Method] 72 mice were subdivided into four groups, group serotypes 4, 5, 12, and PBS (control group), and were injected intraperitoneally with Haemophilus parasuis serotypes 4, 5, 12, and PBS. T lymphocytes and B lymphocytes, cytokines, and Ig were detected. [ Result] The number of T lymphocytes and B lymphocytes in mice on 3 days after infection with Haemophilus parasuis, and gradually decreased as increasing time. But gradually increased in the level of IgG, IFN-γ, and IL-10, and gradually decreased in the level of IgA, IgM, and IgE. The Th1/Th2 level was gradually increased as increasing time, and significantly higher than the control group. However, there were no significant differences between different serotypes Haemophilus parasuis in the level of T lym-phocytes and B lymphocytes, IgA, IgM, IgE, IFN-γ, IL-10, and Th1/Th2, but the level of IgG in group serotypes 4 and 5 were significantly higher than group serotypes 12. [Conclusion] There were no significant differences in the level of peripheral blood lymphocytes, cytokines, and Ig except IgG in mice infected with Haemophilus parasuis serotypes 4, 5, 12 in China.关键词
副猪嗜血杆菌/血清型/淋巴细胞/细胞因子/免疫球蛋白Key words
Haemophilus parasuis/Serotypes/Lymphocytes/Cytokines/Immunoglobulins分类
农业科技引用本文复制引用
陈贯超,廖成水..副猪嗜血杆菌国内流行血清型对小鼠外周血淋巴细胞·细胞因子及免疫球蛋白水平的影响[J].安徽农业科学,2016,44(16):164-166,3.基金项目
国家自然科学基金面上项目(31572489) （31572489）
河南科技大学青年科学基金项目(2015QN033)。 （2015QN033）
