北京中医药大学学报2016，Vol.39Issue(7)：586-589,4.DOI:10.3969/j.issn.1006-2157.2016.07.012
小叶金露梅对醛糖还原酶和α-葡萄糖苷酶的抑制作用
Inhibition of Potentilla parvifolia on alpha-glucosidase and aldose reduc-tase
摘要
Abstract
Objective To study the inhibitory effects on α-glucosidase ( AG ) and aldose reductase ( AR) extracted from Potentilla parvifolia in different solvents , and to find out natural inhibitors of AG and AR.Methods With a combined vitro and vivo experiment design , this study measured the in vitro inhibitory effects of AG and AR extraction from Potentilla Parvifolia in three solvents:ethyl acetate ( total flavonoids ) , petroleum ether and water through AG inhibitors and AR inhibitory activity screening mod-els .In vivo effects of total flavonoids from Potentilla Parvifolia on impaired glucose tolerance of mice were also measured .Results Extraction of Potentilla Parvifolia in total flavonoids demonstrated a stronger in-hibitory effect on AR and AG .Its inhibitory effect on AG was higher than that of acarbose .Meanwhile , both high and low dose of total flavonoids improved glucose tolerance in mice .Conclusion Total fla-vonoids in Potentilla parvifolia exhibits inhibitory effects on AG and AR .关键词
小叶金露梅/α-葡萄糖苷酶/醛糖还原酶/抑制活性/糖耐量Key words
Potentilla parvifolia/α-glucosidase/aldose reductase/inhibitory activity/glucose tolerance分类
中医学引用本文复制引用
孙玉侠,曾阳,张倩茹,余涛,李美华,赵得萍..小叶金露梅对醛糖还原酶和α-葡萄糖苷酶的抑制作用[J].北京中医药大学学报,2016,39(7):586-589,4.基金项目
青海省自然科学基金项目（No．2015-ZJ-907）；青藏高原药用动植物资源重点实验室项目 （）
