吉林大学学报（医学版）2016，Vol.42Issue(4)：757-762,6.DOI:10.13481/j.1671-587x.20160424
中药联合利培酮治疗精神分裂症有效性及安全性的 Meta 分析
Meta-analysis on effectiveness and safety of traditional Chinese medicine combined with risperidone in treatment of schizophrenia
摘要
Abstract
Objective:To approach the effectiveness and safety of traditional Chinese medicine combined with risperidone in the treatment of schizophrenia,and to provide basis for their application in clinic. Methods:The Cochrane,Pubmed,EMBase,CNKI,Wanfang and VIP databases were used to retrieve the randomized controlled trials (RCTs ) and CCTs about traditional Chinese medicine combined with risperidone in the treatment of schizophrenia by computer;and manual retrieval was performed at the same time.The literatures met the standard were collected.The qualities of all the included studies were assessed by Cochrane Handbook and Meta-analysis was performed by use of the RevMan 5.2 software. Results:Fifteen trials and 1 314 patients were included in this review. The qualities of 11 studies were grade C.The Meta-analysis results showed that the clinical effective rate in traditional Chinese medicine combined with risperidone treatment group was higher than that in control group,the difference between two groups was statistically significant (OR= 2.11,95% CI: 1.59 - 2.81,P < 0.01 ).The incidence of adverse drug reactions (insomnia,extrapyramidal symptoms,akathisia)in traditional Chinese medicine combined with risperidone treatment group was lower than that in alone risperidone group, and there were significant differences between two groups (OR=0.25,95%CI:0.17-0.36,P <0.01).Conclusion:Traditional Chinese medicine combined with risperidone is superior to simple application of risperidone in the treatment of schizophrenia,and they can reduce the occurrence of adverse effects of medicine.关键词
精神分裂症/中药/利培酮/Meta 分析/系统评价Key words
schizophrenia/traditional Chinese medicine/risperidone/Meta-analysis/systematic review分类
医药卫生引用本文复制引用
陶茹莹,李淼,张辉..中药联合利培酮治疗精神分裂症有效性及安全性的 Meta 分析[J].吉林大学学报（医学版）,2016,42(4):757-762,6.基金项目
国家自然科学基金资助课题 （）
