吉林大学学报（医学版）2016，Vol.42Issue(4)：763-767,5.DOI:10.13481/j.1671-587x.20160425
Smad2和 Smad4蛋白在乳腺癌组织中的表达及其意义
Expressions of Smad2 and Smad4 proteins in breast carcinoma tissue and significances
摘要
Abstract
Objective:To investigate the expressions of Smad2 and Smad4 in breast carcinoma tissue,and to analyze their relationships with oncogenesis and development of breast carcinoma and significances.Methods:Fifty-three samples of breast ductal carcinoma tissue and 50 samples of surrounding normal tissue were selected.The expression levels of Smad2 and Smad4 in cancer tissue and surrounding normal tissue were detected with immunohistochemical S-P method,and the relationships between the expression levels of Smad2 and Smad4 and the clinicopathologic parameters of breast carcinoma were evaluated.Results:The expression level of Smad2 protein in the breast carcinoma tissue was significantly higher than that in the surrounding normal tissue (z = - 2.08,P <0.05);the expression level of Smad4 protein in breast carcinoma tissue was lower than that in the surrounding normal tissue (z= - 5.01,P < 0.01).In breast carcinoma tissue,the Smad2 and Smad4 expressions were not significantly correlated with age (r=0.035,P >0.05;r=-0.077,P >0.05),tumor size (r= 0.128,P >0.05;r=0.133,P >0.05),lymph node invasion (r =0.163,P >0.05;r =0.006 P >0.05),distant metastasis (r =0.113,P >0.05;r = 0.126,P > 0.05),ER expression (r = 0.056,P > 0.05;r = 0.047,P > 0.05) and PR expression (r=0.129,P >0.05;r=0.107,P >0.05).However,the expression levels of Smad2 and Smad4 were negatively correlated with the expression of HER2 (r = - 0.388,P < 0.01;r = - 0.360,P < 0.01 ) and pathological grade (r = - 0.331,P < 0.05;r = - 0.388,P < 0.01 ).The expression of Smad2 was positively correlated to the expression of Smad4 in breast carcinoma (r=-0.83,P <0.01).Conclusion:The expressions of Smad2 and Smad4 may play an important role in the development of breast carcinoma,and they may be used as the potential biological markers for evaluating the degree of malignancy and prognosis of breast carcinoma.关键词
乳腺肿瘤/细胞信号传导分子 Smad2/细胞信号传导分子 Smad4/免疫组织化学Key words
breast neoplasms/Smad2/Smad4/immunohistochemistry分类
医药卫生引用本文复制引用
刘楠楠,李玉林,孙立伟,姜晶,张继红..Smad2和 Smad4蛋白在乳腺癌组织中的表达及其意义[J].吉林大学学报（医学版）,2016,42(4):763-767,5.基金项目
国家科技部支撑计划项目资助课题（2012BAI19B05）；吉林省吉林市科技局计划项目资助课题 （）
