滨州医学院学报2016，Vol.39Issue(3)：173-175,179,4.
PTTG 基因对非霍奇金淋巴瘤细胞增殖能力的影响
Effects of PTTG gene expression on the reproductive ability of non-hodgkin lymphoma cells
徐理华 1刘瑞磊2
作者信息
- 1. 广州医科大学附属第一医院血液科广州 510230
- 2. 中山大学附属第三医院甲乳外科
- 折叠
摘要
Abstract
Objective To explore the effects of PTTG gene expression on the reproductive ability of non-hodgkin lymphoma cells SUDHL-4 .Methods Non-Hodgkin Lymphoma cells SUDHL-4 was chose to show the biology behavior changes after si-lence PTTG by shRNA ,through the MTT test ,and cell cycle analysis .Results After silence PTTG by shRNA ,the prolifera-tion of SUDHL-4 cells were significantly decreased ,the ratio of G0/G1 and S phase cells was decreased ,the ratio of G2/M cells was increased ,and cell cycle arrested at G2/M ,the difference was statistically significant (P<0.05) .Conclusion The overex-pression of PT TG gene may be related to the occurrence and development of lymphoma ,and it may become the molecular diag-nostics and new therapy target of lymphoma .关键词
非霍奇金淋巴瘤/垂体瘤转化基因/SUDHL-4细胞Key words
non-hodgkin lymphoma/PTTG/SUDHL-4 cell分类
医药卫生引用本文复制引用
徐理华,刘瑞磊..PTTG 基因对非霍奇金淋巴瘤细胞增殖能力的影响[J].滨州医学院学报,2016,39(3):173-175,179,4.
