重庆医学2016，Vol.45Issue(21)：2897-2899,3.DOI:10.3969/j.issn.1671-8348.2016.21.005
超低频经颅磁刺激对脑缺血大鼠认知功能的影响及机制
Influence of ultralow-frequency transcranial magnetic stimulus on cognitive ability of rats with cerebral ischemia and its mechanism
摘要
Abstract
Objective To study the influence of ultralow‐frequency transcranial magnetic stimulus(TMS) on the cognitive a‐bility of rats with cerebral ischemia and its mechanism .Methods 60 healthy rats were divided into 4 groups(15 cases each):A (sham‐operation) ,B(model) ,C(TMS) and D(TMS+ H89) .The escape latency time ,times of passing through platform ,expression level of VEGF ,BDNF and nestin protein were compared among 4 groups .Results In the group A ,the escape latency time was (16 .31 ± 2 .33)s ,times passing through platform were (8 .02 ± 1 .76) times ;in group B ,which were (57 .14 ± 2 .89)s and (3 .15 ± 0 .88) times;in group C ,which were (29 .18 ± 1 .95)s and (5 .44 ± 0 .75) times ;in group D ,which were (45 .87 ± 2 .06)s and (4 .16 ± 1 .02) times .Compared with the group A ,the escape latency time in the group B ,C and D was significantly extended ,more‐over that in the group B was longer than that in the group D and C ,the differences were statistically significant (P<0 .05);the times of passing through platform decreased ,which in the group B was less than that in the group D and C ,the differences had sta‐tistical significance(P<0 .05) .The expression levels of VEGF ,BDNF and nestin had statistical differences among various groups (P<0 .05) .Conclusion Low‐frequency TMS can significantly improve the cognitive ability of rats with cerebral ischemia ,its effect is related to the expression of cAMP‐response element binding protein and its following genes(VEGF and BDNF) .关键词
经颅磁刺激/脑缺血/认知功能Key words
transcranial magnetic stimulus/cerebral ischemia/cognitive ability分类
医药卫生引用本文复制引用
王莉,张燕,余巨明,胡厚祥..超低频经颅磁刺激对脑缺血大鼠认知功能的影响及机制[J].重庆医学,2016,45(21):2897-2899,3.基金项目
国家自然科学基金资助项目（81070101）。 （）
