重庆医学2016，Vol.45Issue(21)：2914-2916,2919,4.DOI:10.3969/j.issn.1671-8348.2016.21.010
不同血液透析方式对慢性肾衰竭患者β2微球蛋白、瘦素、血红蛋白水平的影响及安全性分析
Effect of different hemodialysis modes on serum levels of beta 2 microspheres,leptin and hemoglobin in patients with chronic renal failure and safety analysis
摘要
Abstract
Objective To investigate the influence of different hemodialysis modes on serum levels of beta 2 microspheres , leptin and hemoglobin(Hb) in the patients with chronic renal failure (CRF) and to analyze its safety .Methods Sixty inpatients with CRF in our hospital from January 2014 to January 2015 were selected as the research subjects and divided into the common he‐modialysis group (common HD groups) ,hemodialysis filtration group(HDF group) and the common hemodialysis plus hemoperfu‐sion group(HD+ HP group) according to different treatment methods .The levels of serum leptin ,beta 2 microspheres (β2‐MG) , Hb and erythropoietin (EPO) were measured .The occurrence rates of adverse reactions were observed .The living quality was eval‐uated and conducted the comparative analysis .Results Compared with before hemodialysis ,the levels of serum leptin and β2‐MG levels after the first time of hemodialysis and 6‐month hemodialysis in the three groups were decreased ,moreover the levels in the HD+ HP group were the lowest ,the differences were statistically significant (P<0 .05) ;compared with the common HD group , the levels of Hb and EPO after the first time of hemodialysis and 6‐month hemodialysis in the HDF group and HD+ HP group were increased ,the differences were statistically significant (P<0 .05);the incidence rate of complications after hemodialysis in the HD +HP group was lower than that in the common HD group and the HDF group ,the differences were statistically significant (P<0 .05);the living quality scores of each item after hemodialysis in the HDF group and HD + HP group were superior to those in the common HD group ,moreover the living quality scores in each item in the HD + HP group were higher ,the differences were statisti‐cally significant(P<0 .05) .Conclusion Adopting the HP therapy in the patients with CRF can better reduce the levels of blood leptin andβ2‐MG without affecting the Hb level ,moreover with low occurrence rate of complications ,and the patient′s living quali‐ty is significantly improved after treatment .关键词
慢性肾衰竭/血液透析/血液滤过/血液灌流/并发症Key words
chronic renal failure/hemodialysis/hemofiltration/hemoperfusion/complication分类
医药卫生引用本文复制引用
胡煜琳,李超..不同血液透析方式对慢性肾衰竭患者β2微球蛋白、瘦素、血红蛋白水平的影响及安全性分析[J].重庆医学,2016,45(21):2914-2916,2919,4.基金项目
重庆市科委一般项目（cstc2016jcyjA0343）；重庆市卫生计生委资助项目（2015MSXM058）；永川区自然科学基金项目（Ycstc ，2015nc5004），重庆医科大学附属永川医院院内项目（YJZQN201529，YJSCI201504）。 （）
