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Feiji Recipe Reverses Lung Cancer Immune Escape by Inhibiting the Expression of IDO

Zu-Jun Que Ling Bi Zhi-Yi Zhou Lei Zhou Qing Wang Bin Luo Jian-Wen Liu He-Gen Li Jian-Hui Tian

传统医学研究（英文版）2016，Vol.1Issue(3)：149-155,7.
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传统医学研究（英文版）2016，Vol.1Issue(3)：149-155,7.

Feiji Recipe Reverses Lung Cancer Immune Escape by Inhibiting the Expression of IDO

Feiji Recipe Reverses Lung Cancer Immune Escape by Inhibiting the Expression of IDO

Zu-Jun Que 1Ling Bi 1Zhi-Yi Zhou 2Lei Zhou 2Qing Wang 1Bin Luo 1Jian-Wen Liu 3He-Gen Li 2Jian-Hui Tian1

作者信息

  • 1. Shanghai Institute of Traditional Chinese Medicine, Institute of TCM 0ncology, 725 South Wanping Rd., Shanghai 200032, China
  • 2. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, National Clinical Research Centre for Traditional Chinese Medicine and 0ncology, 725 South Wanping Rd., Shanghai 200032, China
  • 3. State Key Laboratory of Bioreactor Engineering and Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China, University of Science and Technology, #268, 130 Meilong Rd, Shanghai, 200237, China
  • 折叠

摘要

Abstract

肿瘤细胞能够通过多种机制逃避T细胞介导的免疫识别，而吲哚胺2,3-双加氧酶（IDO）是一种色氨酸代谢酶，它能够通过降解色氨酸，同时产生犬尿氨酸，从而诱导免疫耐受，最终导致肿瘤细胞逃避宿主免疫杀伤。肺积方是由12位中药组成的复方，已被证实能够干预免疫逃逸，提高肺癌患者的免疫监视能力。为进一步探讨IDO在肺癌的发生发展过程中的生物学作用和肺积方对肿瘤免疫逃逸的干预机制，本研究构建了过表达IDO的小鼠肺癌细胞株（2LL-EGFP-IDO）。IDO的过表达不影响2LL细胞的增殖。高效液相检测结果显示2LL-EGFP-IDO细胞能够有效的代谢培养基中的色氨酸，同时产生其下游代谢产物犬尿氨酸。而共培养体系中，肺积方干预后能够抑制IDO的表达，从而上调CD8+T细胞的比例。我们的研究表明肺积方能够通过抑制IDO的表达，上调CD8+T细胞的比例，以增强免疫应答、逆转肿瘤细胞的免疫逃逸。

关键词

Indoleamine 2/3-dioxygenase (IDO)/Feiji Recipe/Immune escape/IDO+ mouse Lewis lung cancer cell line/Non-small cell lung cancer

Key words

Indoleamine 2/3-dioxygenase (IDO)/Feiji Recipe/Immune escape/IDO+ mouse Lewis lung cancer cell line/Non-small cell lung cancer

引用本文复制引用

Zu-Jun Que,Ling Bi,Zhi-Yi Zhou,Lei Zhou,Qing Wang,Bin Luo,Jian-Wen Liu,He-Gen Li ,Jian-Hui Tian..Feiji Recipe Reverses Lung Cancer Immune Escape by Inhibiting the Expression of IDO[J].传统医学研究（英文版）,2016,1(3):149-155,7.

基金项目

This Study was supported by National Natural Science Foundation of China (Grant No:81173224，81373621), Shanghai Municipal Committee of Science and Technology (No.11ZR1437000), Longhua Medical Project (D-11) Jian-hui Tian and Specific Research Program from National Clinical Base of TCM(No. JDZX2012125) （Grant No:81173224，81373621）

传统医学研究（英文版）

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