南方医科大学学报2016，Vol.36Issue(7)：927-931,5.DOI:10.3969/j.issn.1673-4254.2016.07.09
精氨酸加压素基因rs66818855A/G和rs1078152C/T在广西健康人群中的分布
Distribution of single nucleotide polymorphisms of arginine-vasopressin gene in Guangxi healthy population
摘要
Abstract
Objective To study the distribution of single nucleotide polymorphisms (SNP) of arginine-vasopressin (AVP) gene rs66818855 and rs1078152 in Chinese Guangxi healthy population in comparison with that in different ethnic populations. Methods Polymerase chain reaction-single base extension (PCR-SBE) and DNA sequencing were used to detect the allele and genotype frequencies of AVP gene among 303 Chinese healthy individuals in Guangxi, China, and the results were compared with the reported frequencies in 4 other populations (HapMap-CEU, HapMap-YRI, HapMap-JPT, and HapMap-HCB) from Human Genome Project group (HapMap) data. Results We found significant AVP gene polymorphisms in this Guangxi healthy population. The frequencies of allele and genotype of AVP gene rs66818855 and rs1078152 polymorphisms in this Guangxi population differed significantly from those in HapMap-CEU population (P<0.01), and allele frequencies of AVP gene rs66818855 polymorphism differed significantly from those in HapMap-YRI populations (P<0.05). Conclusion The distribution pattern of AVP gene polymorphisms in this Guangxi population is significantly different from that in other ethnic populations, which might account for the difference in the morbidity of AVP-related disease among different ethnic groups and may have important indications in the study of population genetics and anthropology.关键词
精氨酸加压素/基因/单核苷酸多态性/种族Key words
arginine-vasopressin gene/gene polymorphisms/ethnics引用本文复制引用
向阳,郭静,彭友帆,蓝艳,黄华佗,韦叶生..精氨酸加压素基因rs66818855A/G和rs1078152C/T在广西健康人群中的分布[J].南方医科大学学报,2016,36(7):927-931,5.基金项目
国家自然科学基金（81260234，81560552）；2015年广西研究生创新课题（YCSZ2015221）；右江民族医学院校级课题（yy2015ky003）Supported by National Natural Science Foundation of China (81260234，81560552) （81260234，81560552）
