南方医科大学学报2016，Vol.36Issue(7)：932-935,4.DOI:10.3969/j.issn.1673-4254.2016.07.10
呼出气一氧化氮增高可预测亚急性咳嗽患者吸入激素治疗的反应性
High fractional exhaled nitric oxide may predict response to inhaled corticosteroid therapy in patients with subacute cough
摘要
Abstract
Objective To evaluate fractional exhaled nitric oxide (FENO) level in patients with subacute cough and its value in predicting the patients' response to inhaled corticosteroids (ICS) treatment. Methods A total of 100 patients with persistent cough lasting more than 3 weeks were enrolled, including 52 patients with subacute cough and 48 with chronic cough. FENO, spirometry, and responses to ICS therapy of the patients were evaluated. Results The recruited patients had a median (inter-quartile ranges) FENO level of 19 ppb (12-30 ppb). Patients with chronic cough had a significantly higher median FENO level than those with subacute cough (20.5 vs 16 ppb; Z=-2.245, P=0.025). A FENO level ≥25 ppb was recorded in 15 (28.8%) patients with subacute cough, as compared with 20 (41.6%) in patients with chronic cough (χ2=1.801, P=0.179). With a FENO≥25 ppb as the critical value to justify ICS treatment, 15 patients with subacute cough received ICS and 14 (93.3%) of them showed obvious relief of cough after 2 weeks of therapy, a response rate similar to that of 85.0%(17/20) in patients with chronic cough receiving the treatment (χ2=0.588, P=0.443). In patients with subacute cough, those with cough variant asthma (CVA) or eosinophilic bronchitis (EB) had a significantly higher median FENO level than those with postinfectious cough [(16 (11-31) ppb vs 11 (8-19) ppb, P<0.01]. In the etiological analysis, CVA or EB was identified in 23 (44.2%) of the patients with subacute cough, as compared 21 (43.8%) in patients with chronic cough (χ2=0.002, P=0.961). Conclusion FENO may be an important indicator for etiological diagnosis of subacute cough and for predicting the response to ICS treatment.关键词
呼出气一氧化氮/亚急性咳嗽/慢性咳嗽/咳嗽变异性哮喘/激素反应性Key words
fractional exhaled nitric oxide/subacute cough/chronic cough/corticosteroid response引用本文复制引用
叶艳梅,蔡绍曦,赵海金,王燕红,倪丽,梁健鹏,郁伟伟,吴月仙,赵文驱,熊婧,姚利红..呼出气一氧化氮增高可预测亚急性咳嗽患者吸入激素治疗的反应性[J].南方医科大学学报,2016,36(7):932-935,4.基金项目
国家自然科学基金（81270089，81470228）；广东省自然科学基金（2015A030313236）；广东省科技计划项目（2016A020215117）；南方医院院长基金（2013C028）Supported by National Natural Science Foundation of China （）
