南方医科大学学报2016，Vol.36Issue(7)：941-946,6.DOI:10.3969/j.issn.1673-4254.2016.07.12
心脏瓣膜钙化对维持性血液透析患者心血管预后的影响
Association of heart valve calcification with cardiovascular outcomes in patients on maintenance hemodialysis
摘要
Abstract
Objective To investigate the impact of heart valve calcification (HVC) on cardiovascular outcomes in patients on maintenance hemodialysis (MHD). Methods We enrolled 302 Chinese patients on MHD between 2009 and 2011 including 99 with HVC identified by echocardiography screening. All the patients were followed up for 2 years and survival analysis was performed with all-cause mortality, cardiovascular mortality and new onset cardiovascular events as the endpoints. Cox regression analysis was used for analyzing the impact of heart valve calcification on the cardiovascular outcomes of the patients. Results The mean age of the total patients was 58.2±15.0 years when receiving the initial MHD, and 53.6%were male patients. The overall mortality, cardiovascular mortality and new on-set cardiovascular events in HVC and non-HVC groups were 30.3% vs 16.3%, 22.2% vs 6.9%, and 48.5% vs 25.6%, respectively (P<0.05). Kaplan-Meier survival analysis showed a significant difference in all-cause mortality (P=0.006), cardiovascular mortality (P<0.001) and new-onset cardiovascular events (P<0.001) between HVC and non-HVC groups. After adjustment, Cox regression analysis identified HVC as a risk factor for increased all-cause mortality (HR=1.88; 95% CI: 1.11-3.19), cardiovascular mortality (HR=3.47, 95% CI: 1.76-6.84) and cardiovascular events (HR=1.64, 95% CI: 1.09-2.47). Conclusions HVC is an independent risk factor for increased cardiovascular mortality and new cardiovascular events in patients on MHD.关键词
心脏瓣膜钙化/血液透析/死亡/心血管事件Key words
heart valvular calcifition/hemodialysis/mortality/cardiovascular events引用本文复制引用
李志莲,梁华般,王力芬,史伟,何朝生,陈源汉,梁馨苓,董伟,李锐钊,黎思嘉,徐丽霞,冯仲林..心脏瓣膜钙化对维持性血液透析患者心血管预后的影响[J].南方医科大学学报,2016,36(7):941-946,6.基金项目
国家自然科学基金青年基金（81200544）；国家自然科学基金面上项目（81570609）；“十二五”国家科技支撑计划项目（2011BAI10B08）；广东省科技计划基金（2015A020210069）Supported by Natural Science Foundation for the Youth (NSFY) of China (81200544) （NSFY）
Supported by National Natural Science Foundation of China (81570609) （81570609）
