南方医科大学学报2016，Vol.36Issue(7)：964-968,5.DOI:10.3969/j.issn.1673-4254.2016.07.16
广西人群中白介素-33基因rs1891385A/C、rs10975519C/T多态性的分布特点
Distribution characteristics of rs1891385A/C and rs10975519C/T polymorphisms of interleukin-33 gene in Guangxi population
摘要
Abstract
Objective To explore the race- and gender-specific distribution characteristics of rs1891385A/C and rs10975519C/T polymorphism of interleukin-33 (IL-33) gene in Zhuang and Han populations. Methods The polymorphisms of rs1891385A/C and rs10975519C/T of IL-33 gene in 283 subjects from Guangxi Zhuang Autonomous Region were analyzed with single base extension (PCR-SEB) and DNA sequencing to analyze the differences in their distribution frequencies between genders and between Zhuang and Han populations. Results Three genotypes (AA, AC and CC) were found in rs1891385A/C with frequencies of 64.3%, 32.5% and 3.2%, respectively. The genotype and allele frequencies of rs1891385A/C in this Guangxi population showed no significant difference between Zhuang and Han subpopulations and between genders (P>0.05), but differed significantly from those in European and African black populations (P<0.01). Three genotypes (CC, CT and TT) were identified in rs10975519C/T with frequencies of 34.3%, 53.0%, and 12.7%, respectively, showing no significant ethnic or gender-specific differences in this population (P>0.05). The genotype frequency of rs10975519C/T in this population differed significantly from those in the European and Japanese populations (P<0.01), but the allele frequencies only showed significant differences from those in the European population (P<0.01). Conclusion rs1891385A/C and rs10975519C/T polymorphisms of IL-33 gene show a race-specific difference.关键词
IL-33/基因多态性/广西人群Key words
interleukin-33/gene polymorphism/Guangxi population引用本文复制引用
郭静,向阳,黄华佗,彭友帆,韦叶生,蓝艳..广西人群中白介素-33基因rs1891385A/C、rs10975519C/T多态性的分布特点[J].南方医科大学学报,2016,36(7):964-968,5.基金项目
国家自然科学基金（81260234，81560552）；广西研究生教育创新计划项目（YCSZ2015223）；右江民族医学院校级课题（yy2015zd001）Supported by National Natural Science Foundation of China (81260234,81560552) （81260234,81560552）
