南方医科大学学报2016，Vol.36Issue(7)：1024-1028,5.DOI:10.3969/j.issn.1673-4254.2016.07.27
苦参碱/壳聚糖/羧甲基壳聚糖载药膜的制备及其体外释放行为分析
Preparation and in vitro drug release behavior of a novel matrine-loading chitosan/glycerol film
摘要
Abstract
Objective To prepare a drug-loading film using chitosan and carboxymethyl chitosan as the carrier materials for delivering matrine to oral ulcers. Methods Matrine-loading films using chitosan or carboxymethyl chitosan as the carrier materials were prepared by solution casting method and orthogonal experiment at room temperature. The mechanical properties, surface morphology and drug-loading capacity of the drug-loading film were characterized using tensile test, scanning electron microscopy (SEM), swelling test and in vitro drug release test. Results When the molecular weight of chitosan was 650 000 and the mass ratio of chitosan/glycerol was 1∶1.4, the prepared film had the maximum mechanical strength and tensile modulus reaching 0.7875 MPa. SEM observation showed that matrine aggregated at the bottom of the drug-loading film with an asymmetrical distribution. The in vitro drug release test showed that the film had a high drug-loading capacity and a sustained drug release property. The duration of drug release from the drug-loading film was prolonged as the molecular weight of chitosan increased, reaching 23 h when the molecular weight of chitosan was 650 000. The duration of drug release was further increased to 108 h when the bottom of the drug-loading film was coated with a layer of 1% carboxymethyl chitosan. Conclusion The matrix materials of the drug-loading film are natural, green, nontoxic and biodegradable, and the preparation of the film is simple without using large quantities of organic solvents. The novel drug-loading film can obviously prolong the duration of drugs release for better local drug delivery to oral ulcers in a sustained manner.关键词
壳聚糖/苦参碱/羧甲基壳聚糖/载药膜/体外释放Key words
matrine/chitosan/carboxymethyl chitosan/drug-loading film/drug release behavior引用本文复制引用
张春雷,杨天剑,饶华新,张子勇..苦参碱/壳聚糖/羧甲基壳聚糖载药膜的制备及其体外释放行为分析[J].南方医科大学学报,2016,36(7):1024-1028,5.基金项目
国家自然科学基金（31272078）Supported by National Natural Science Foundation of China (31272078) （31272078）
