口腔疾病防治2016，Vol.24Issue(7)：395-401,7.DOI:10.12016/j.issn.2096-1456.2016.07.004
复合干细胞膜片移植修复后的牙周组织与正常牙周组织对正畸力反应的差异性研究
Study on the differences of reconstructive periodontium by stem cell sheets and normal periodontium under the orthodontic force
摘要
Abstract
Objective To discuss the feasibility of orthodontic treatment for regenerated periodontal tissues by com⁃paring the difference of tooth movement under orthodontic forces between the normal periodontal tissues and the recon⁃structed periodontal tissues by the composite cell sheets of dental follicle cells (DFCs) and periodontal ligament stem cells (PDLSCs). Methods Six adult male beagles were selected for experiment animals. The first premolar in all four quadrants of each beagle were extracted and a bone defect were made in the same size (4 mm × 4 mm × 4 mm) distal to the extraction sockets. The upper left and the lower right quadrants were divided into the regeneration group by trans⁃plantation of the composite cell sheets while the upper right and lower left quadrants were control group without trans⁃plantation. 12 weeks after transplantation, the orthodontic forces were introduced to move the second premolar mesially with a force value 150 g. Measurements were done after 4 weeks of traction to record the movement of the tooth. And compare the difference between the regeneration group and control group by the statistical analysis. Results DFCs/PDLSCs composite cell sheets repaired the periodontaltissue and formed the typical alveolar bone⁃periodontal membrane⁃cementum structurewhich shows good histological characteristics. experimental group and control group show no statisti⁃cal difference in the rate of tooth movement (P>0.05). Conclusion The periodontal tissues regenerated by this kind of the composite cell sheet showed a good response to mechanical stimulation.关键词
干细胞/细胞膜片/牙周组织再生/牙囊细胞/正畸Key words
Stem cell/Cell sheet/Periodontal regeneration/Dental follicle cells/Orthodontics分类
口腔医学引用本文复制引用
吴琼,金作林,李欣,王丽颖,刘佳..复合干细胞膜片移植修复后的牙周组织与正常牙周组织对正畸力反应的差异性研究[J].口腔疾病防治,2016,24(7):395-401,7.基金项目
国家自然科学基金 （）
