口腔疾病防治2016，Vol.24Issue(8)：445-448,4.DOI:10.12016/j.issn.2096-1456.2016.08.002
慢性牙周炎对OLETF大鼠肾脏功能的影响
Effects of chronic periodontitis on renal function in OLETF rats
摘要
Abstract
Objective To investigate the effects of chronic periodontitis on kidney function of OLETF rats. Meth⁃ods 30 spontaneous type 2 diabetes mellitus (T2DM) OLETF rats aged 4 weeks were selected as the experimental ob⁃jects, and 20 LETO rats with normal sugar tolerance of the same species and the same week age were selected as the control group. When the rats arrived the glucose tolerance damage stage at the age of 36 weeks, 26 OLETF rats (O group) were divided into diabetes mellitus combined periodontitis group (O CP(+) group) and diabetic group (O CP(-) group) randomly, and 20 LETO rats (L group) were randomly divided into periodontitis group (L CP(+) group) and normal group (L CP(-) group). Then the chronic periodontis models were established on the rats in the O CP(+) group and L CP(+) group, by silk thread ligation combined with coated bacteria. All the rats were executed at the 56 weeks age, when the models were established for 20 weeks. The serum was collected and analyzed by automatic biochemical machine to mea⁃sure the biochemical indicators of renal function, including the following 4 indexes:serum albumin (ALB), total protein (TP), urea and creatinine (CR). Results The levels of serum TP and ALB decreased significantly in O group than in L group (P<0.01), as the same result when compared O CP(+) group with O CP(-) group (P<0.01), however, there was no significant difference when compared L CP(+) group to L CP(-) group. Serum CR was significantly higher in O group than in L group (t=9.099, P=0.005), the same as that in O CP(+) group when compared with O CP(-) group (t=4.443, P<0.001), while there was no significant difference when compared L CP(+) group to L CP(-) group. Serum urea levels in O group was significantly higher than in L group (t=5.684, P=0.024), While there was no significant difference between O CP(+) group and O CP (-) group (t=1.484, P=0.160), the same as that between L CP(+) group and L CP(-) group (t=0.075, P=0.932). Conclusion It shows that chronic periodontitis may not cause changes in kidney function in normal rats. However, in the case of T2DM, chronic periodontitis may increase the existing kidney damage. It indicates that T2DM and chronic periodontitis may have interactions in the development of diabetic kidney disease.关键词
慢性牙周炎/2型糖尿病/糖尿病肾脏疾病/总蛋白/OLETF大鼠Key words
Chronic periodontitis/Type 2 diabetes/Diabetic kidney disease/Total protein/OLETF rats分类
医药卫生引用本文复制引用
王丹,倪佳,苏媛,轩东英,章锦才..慢性牙周炎对OLETF大鼠肾脏功能的影响[J].口腔疾病防治,2016,24(8):445-448,4.基金项目
广东省医学科研基金（B2014027）；国家自然科学基金（81371151）；国家自然青年科学基金 （）
