口腔疾病防治2016，Vol.24Issue(8)：449-453,5.DOI:10.12016/j.issn.2096-1456.2016.08.003
4种修复金属材料对炎性牙周组织炎症因子表达的影响
Effects of 4 kinds of dental metal alloy extraction on expression of inflanmatory cytokine in the inflamed peri-odontal tissue
摘要
Abstract
Objective To evaluate the inflammatory cytokine expressions of inflamed human gingival fibroblast cells (iHGFs) stimulated in 4 types of dental metal extractions. Methods Inflamed gingival tissues from 10 patients with peri⁃odontitis were collected, and primary iHGFs were cultured. The cells were stimulated by Co⁃Cr, Ti alloy, pure Ti and Au⁃Pd alloy extractions respectively, and DMEM was used as blank control. Protein productions of pro⁃inflammatory media⁃tors and related mRNA expressions were measured with ELISA and RT⁃PCR. Statistics were tested with Wilcoxon matched⁃pairs test. Results ELISA and RT⁃PCR results showed the protein and mRNA expressions of interleukin⁃6, in⁃terleukin⁃1β, tumor necrosis factor⁃αin Ni⁃Cr and Ti alloy groups were both higher than the control group (z=2.803, P=0.005). However, there was no significant difference in pure Ti and Au⁃Pd groups compared with the control group (P>0.05). Conclusion Pure Ti and Au⁃Pd alloy have a better biocompatibility than Co⁃Cr and Ti alloy in inflamed periodon⁃tal tissues.关键词
牙龈成纤维细胞/钛合金/钴铬合金/纯钛/金钯合金Key words
Gingival fibroblast cell/Co-Cr alloy/Ti alloy/Ti/Au-Pd alloy分类
医药卫生引用本文复制引用
吴丽霞,张丽丽,王远勤,李镭,梁姗姗..4种修复金属材料对炎性牙周组织炎症因子表达的影响[J].口腔疾病防治,2016,24(8):449-453,5.基金项目
国家自然科学基金 （）
