国际医药卫生导报2016，Vol.22Issue(13)：1842-1845,4.DOI:10.3760/cma.j.issn.1007-1245.2016.13.005
高流量CVVH治疗严重腹腔感染的疗效探究
An investigation of the efficacy of high flow continuous veno-venous hemofiltration in the treatment of severe intra-abdominal infection
摘要
Abstract
Objective To investigate the clinical efficacy of high flow continuous veno-venous hemofiltration (CVVH) in the treatment of severe intra-abdominal infection.Methods 83 patients with severe intraabdominal infection admitted to intensive care unit (ICU) were recruited into this study.Patients were divided into 3 groups.Patients in high flow CVVH group (n=33) and low flow CVVH group (n=29) received either high flow or low flow CVVH.CVVH was not performed for patients in control group.All patients received comprehensive treatment routinely performed at ICU.Results APACHE Ⅱ score in high flow CVVH group significantly declined ever since 12 h post-treatment (P＜0.05),and significantly lower than those in control group (P＜0.05).Inflammatory factors,including TNF-α,IL-6,and CRP showed a trend of decline after high flow and low flow CVVH treatment.24 h after treatment,the values of above three inflammatory factors in high flow CVVH group were significantly lower than those in control group (P＜0.05).The length of hospitalization in high flow CVVH group was significantly less than that in control group and low flow CVVH group (P＜0.05).Improvement rate in high flow CVVH group was better than that in control group (P＜0.05).Conclusions High flow CVVH can efficiently relieve the symptoms of patients with severe intra-abdominal infection,improve APACHE Ⅱ score and patients' prognosis,which could be related to efficient clearance of multiple inflammation factors by high flow CVVH.关键词
严重腹腔感染/炎症因子/连续性静脉-静脉血液滤过Key words
Severe intra-abdominal infection/Inflammation factors/Continuous veno-venous hemofiltration引用本文复制引用
郭湖坤,谢少庭,郭铃苹,李智业,陈纪平..高流量CVVH治疗严重腹腔感染的疗效探究[J].国际医药卫生导报,2016,22(13):1842-1845,4.基金项目
汕头市科技计划项目(汕府科[2014]62号)Science and Technology Plan Project of Shantou ([2014]62) （汕府科[2014]62号）
