摘要
Abstract
Objective To explore the clinical effects of fasudil or nimodipine in the treatment of cerebral vasospasm after subarachnoid hemorrhage(SAH).Methods 92 patients with cerebral vasospasm after SAH treated at our hospital from September,2012 to June,2014 were selected as study objects and randomly divided into a control group (46 cases),treated with fasudil,and an observation group (46 cases),treated with nimodipine.The efficacy and safety were compared between these two groups after the treatment.Results After 3 weeks' treatment,the incidence of cerebral vasospasm was 4.35％ in the observation group and 6.52％ in the control group,with no statistical difference (P＞0.05).After the treatment,Glasgow prognosis score showed that the effective rate was 84.78％ in the observation group and 69.57％ the control group,with a statistical difference (P＜0.05).The incidence of adverse reactions,such as fever,headache,and facial congestion,was 8.70％ in the observation group and 23.91％ in the control group after the treatment,with a statistical difference (P＜0.05).Conclusions Fasudil and nimodipine for the improvement and prognosis of cerebral vasospasm both has high clinical effect,but fasudil is safer and more beneficial to long-term prognosis,so it is worth being clinically generalized.关键词
法舒地尔/蛛网膜下腔出血/尼莫地平/脑血管痉挛Key words
Fasudil/Subarachnoid hemorrhage/Nimodipine/Cerebral vasospasm
