国际医药卫生导报2016，Vol.22Issue(14)：2167-2169,3.DOI:10.3760/cma.j.issn.1007-1245.2016.14.051
血清HE4与CA125联合检测在早期卵巢癌诊断中的应用价值探讨
Combined detection of serum HE4 and CA125 in diagnosis of early ovarian cancer
刘秋红 1卢艳 1王博 2邹颖 1李红云1
作者信息
- 1. 410008 长沙,湖南省妇幼保健院
- 2. 410005 长沙,湖南省人民医院
- 折叠
摘要
Abstract
Objective To investigate the application value of human epididymis protein 4 (epididymis protein-4 human,HE4) and carbohydrate antigen 125 (CA125) in the diagnosis of early ovarian cancer.Methods 20 patients with ovarian cancer (group A) and 20 patients with benign ovarian lesions (group B) treated at our hospital from August,2014 to May,2015 were selected.40 healthy subjects taking physical examination during the same period were selected as a control group.The serum levels of HE4 and CA125 of these three groups were measured.Results The serum levels of HE4 and CA125 was (483.13±26.98) pmol/L and (345.81±40.34)pmol/L in group A,which were significantly higher than those in the control group and group B (P＜0.05).The detection sensitivity of the combination of HE4 CA125 was higher than that of either HE4 or CA125.The specificity of the combination of HE4 CA125 was higher than that of CA125 and lower than that of HE4(P＜0.05).Conclusions The value of the combined detection of serum HE4 and CA125 in the diagnosis of early ovarian cancer is better than that of either one and can significantly improve the diagnostic sensitivity and provide professional reference for the diagnosis of the disease,so it is worth being clinically generalized.关键词
卵巢癌/HE4/CA125/诊断Key words
Ovarian carcinoma/HE4/CA125/Diagnosis引用本文复制引用
刘秋红,卢艳,王博,邹颖,李红云..血清HE4与CA125联合检测在早期卵巢癌诊断中的应用价值探讨[J].国际医药卫生导报,2016,22(14):2167-2169,3.
