高师理科学刊2016，Vol.36Issue(7)：49-51,3.DOI:10.3969/j.issn.1007-9831.2016.07.012
β-环糊精对甲硝唑包合作用的热力学研究
Study on the complexation thermodynamics of the β-cyclodextrin with metronidazole
摘要
Abstract
The molar ratio ofmetronidazole withβ-CD were investigated by Job′s method.The thermodynamic parameters and stability constants during the inclusion process were investigated by the phase solubility method at different temperatures.It was suggested that complexation should be formated in solution at 1∶1 molar ratio.The phase diagram was AL type.The stability constants and the solubilities decrease with the temperature increasing.DS,DH,DGwere all of negative value,illustrating the complexation of metronidazole withβ-CD is enthalpy driven which could proceed spontaneously along with the release of heat.关键词
β-环糊精/甲硝唑/相溶解度法/热力学函数Key words
β-cyclodextrin/metronidazole/phase-solubility method/thermodynamic parameters分类
医药卫生引用本文复制引用
张亚安,丰久彪,季明星,周晶,徐滢,任丽萍..β-环糊精对甲硝唑包合作用的热力学研究[J].高师理科学刊,2016,36(7):49-51,3.基金项目
江苏省高等学校大学生实践创新训练计划项目（scx1623）；东南大学成贤学院教学改革项目 （）
