摘要
Abstract
Objective To investigate the changes of creatine kinase MB (CK-MB), myohemoglobin (MYO), brain natriuretic peptide (BNP), cardiac troponin-I (cTnI) levels in full-term and premature infants and their clinical significance .Methods A total of 211 cases of neonates were chosen as research objects .All these infants were delivered at Huai ’ an First People ’ s Hospital of Nanjing Medical University from September 2012 to October 2015.Comparisons of the differences in serum CK-MB, MYO, BNP, and cTnI levels, and the incidence rate of neonatal asphyxia and neonatal hypoxic-ischemic encephalopathy ( HIE) were carried out between full-term infants and premature infants.Besides, comparison of the levels of serum CK-MB, MYO, BNP and cTnI was also conducted among neonates with neonatal asphyxia , neonates with hypoxic ischemic encephalopathy ( HIE) and healthy neonates .Correlations among CK-MB, MYO, BNP and cTnI levels in neonates were also analyzed .Results Full-term infants had lower levels of CK-MB and MYO in serum than preterm infants, and the differences were statistically significant (t value was 7.057 and 13.029, respectively, both P<0.05).There was no significant difference in serum BNP and cTnI between full-term and preterm infants (all P >0.05).The incidence rate of neonatal asphyxia and neonatal HIE were lower in full-term infants than that of the preterm infants .The differences were statistically significant (χ2 value was 13.642 and 10.913, respectively, both P<0.05).The levels of CK-MB, MYO, BNP and cTnI in the serum of neonates with asphyxia or neonatal HIE were higher than those of the healthy neonates .The differences were statistically significant ( t value ranged from 4.088 to 21.802, all P <0.05).Serum CK-MB level was positively correlated with the level of MYO ( r =0.356, P <0.001). Conclusion The levels of CK-MB and MYO in serum of full-term infants are lower than those of the preterm infants .The levels of CK-MB, MYO, BNP and cTnI in the serum of neonates with asphyxia or HIE are higher than those of the healthy neonates .Serum CK-MB level is positively correlated with the level of MYO in neonates .关键词
足月儿/早产儿/新生儿窒息/新生儿缺血缺氧性脑病Key words
full-term infants/preterm infants/neonatal asphyxia/neonatal hypoxic-ischemic encephalopathy ( HIE)分类
医药卫生
