中国妇幼健康研究2016，Vol.27Issue(7)：808-810,3.DOI:10.3969/j.issn.1673-5293.2016.07.007
性早熟 GnRH-a治疗后与青春期多囊卵巢综合征发生的相关性
Correlation between idiopathic central precocious puberty treated with GnRH-a and the incidence of polycystic ovarian syndrome
彭刚 1丁明 1张琴 1杨方华 1杨斌让1
作者信息
摘要
Abstract
Objective To explore the correlation between idiopathic central precocious puberty ( ICPP) treated with gonadotropin releasing hormone analogs ( GnRH-a) and the incidence of polycystic ovarian syndrome ( PCOS) .Methods A retrospective cohort study was carried out on girls aged from 13 to 18.All these girls were diagnosed with ICPP and had menses for more than 3 years.Among them, 224 girls were treated with GnRH-a and were recruited in research group .The rest 64 girls who didn't undergo GnRH-a treatment were chosen in control group.Incidence rate of pubertal PCOS was compared between two groups .Results The height of girls in the research group at the end of the follow-up was significantly higher than that of the the control group (t=2.784, P<0.05).However, there was no significant difference in age, weight and BMI between two groups (t value was 0.363, 0.740 and 0.863, respectively, all P>0.05).The incidence rate of PCOS in the research group and control group during the follow-up was 7.14%and 4.69%, respectively.No significant difference was identified between two groups (χ2 =0.487, P >0.05).Conclusions Treating ICPP with GnRH-a does not increase the risk of incidence of PCOS .关键词
多囊卵巢综合征/长效促性腺激素释放激素类似物/青春期/回顾性队列研究Key words
polycystic ovary syndrome ( PCOS)/GnRH-a/puberty/retrospective cohort study分类
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彭刚,丁明,张琴,杨方华,杨斌让..性早熟 GnRH-a治疗后与青春期多囊卵巢综合征发生的相关性[J].中国妇幼健康研究,2016,27(7):808-810,3.
