中国妇幼健康研究2016，Vol.27Issue(7)：859-860,863,3.DOI:10.3969/j.issn.1673-5293.2016.07.024
CD4＋CD25＋FOXP3＋调节性 T细胞在牛奶蛋白过敏发生及耐受中的作用
Roles of CD4 +CD25 +FOXP3 +regulatory T cells in pathogenesis and tolerance for cow’ s milk allergy
杨希晨 1刘静 1华亚军1
作者信息
- 1. 东南大学医学院附属江阴市人民医院儿科，江苏江阴214400
- 折叠
摘要
Abstract
Objective To explore the roles of CD4 +CD25 +FOXP3 +regulatory T cells in the pathogenesis of and tolerance induction against cow’s milk allergy.Methods A total of 20 children who were allergic to cow’s milk were chosen as research objects.All these children were diagnosed at the department of pediatrics in Jiangyin People ’ s Hospital Affiliated to Southeast University Medical College from January 2013 to January 2015.Over the same period, 20 healthy children were selected in control group .Children with cow’s milk allergy were given completely hydrolyzed or deeply hydrolyzed protein formulas for six months .Six months later , a food challenge test was performed.Among them, 15 children were tolerant to cow’s milk while 3 children were not.Levels of CD4 +CD25 +FOXP3 +regulatory T cells in peripheral blood were measured before and after treatment .Besides, comparison of the CD4 +CD25 +FOXP3 +regulatory T cells in children with cow’s milk allergy before and after the treatment was carried out .In addition, intergroup comparison of the CD4 +CD25 +FOXP3 +regulatory T cells was conducted .Moreover, comparison of the CD4 +CD25 +FOXP3 +regulatory T cells was also performed between children who developed tolerance to cow ’ s milk and who were still allergic to cow ’ s milk.Results The level of CD4 +CD25 +FOXP3 +regulatory T cells was significantly lower in children with cow ’s milk allergy than the control group (3.73 ±0.42% vs 6.9 ± 0.35%, t=2.22, P<0.05).After treatment, a remarkable increase was identified in the level of CD 4 +CD25 +FOXP3 +regulatory T cells when compared with the situation before treatment (5.18 ±0.81% vs 3.73 ±0.42%, t=2.10, P<0.05).After treatment, the level of CD4+CD25 +FOXP3 +regulatory T cells was significantly higher in children who developed tolerance to cow ’ s milk than those who were still allergic to cow’s milk (5.36 ±0.76%vs 4.28 ±0.36%,t=2.31,P<0.05).Conclusion CD4 +CD25 +FOXP3 +regulatory T cells can help to reduce the incidence of allergy to cow ’ s milk protein and help to trigger immune tolerance .关键词
牛奶蛋白过敏/CD4+CD25+FOXP3+调节性T细胞/儿童/免疫耐受Key words
cow’ s milk allergy/CD4 +CD25 +FOXP3+regulatory T cells/children/immune tolerance分类
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杨希晨,刘静,华亚军..CD4＋CD25＋FOXP3＋调节性 T细胞在牛奶蛋白过敏发生及耐受中的作用[J].中国妇幼健康研究,2016,27(7):859-860,863,3.
