临床与病理杂志2016，Vol.36Issue(7)：909-913,5.DOI:10.3978/j.issn.2095-6959.2016.07.004
原发性中枢神经系统非霍奇金淋巴瘤临床分析
Clinic analyses of primary central nervous system non-Hodgkin’s lymphoma
刘畅 1许春伟 2张立英 3张岩4
作者信息
- 1. 北京军区总医院肿瘤科，北京 100700
- 2. 军事医学科学院附属医院病理科，北京 100071
- 3. 北京军区总医院病理科，北京 100700
- 4. 北京军区总医院附属八一脑科医院，北京 100700
- 折叠
摘要
Abstract
Objective: To investigate the clinical features, treatment and prognosis of primary central nervous system non-Hodgkin’s lymphoma (PCNSL).Methods: Retrospectively analysed clinical data and treatment of four cases of PCNSL. hTe survival and recurrence were observed.Results: Four cases of PCNSL patients were all males, aged 46 to 76 years, with a median age of 58.75 years. Lesions were located in the lower section of the brainstem bilateral thalamus, right ventricle, right occipital lobe, and right cerebellum, headache caused by intracranial hypertension is the main clinical symptoms. All 4 cases were given large doses of MTX-based chemotherapy plus whole brain radiotherapy atfer surgery; follow-up for 3 years, 1 patient died of recurrence atfer surgery, 3 patients survived.Conclusion: PCNSL occurs mainly in middle-aged men, intracranial hypertension is the main clinical symptom, and B cell subtype predominant. HD-MTX combined with whole brain radiation therapy is effective and feasible in the treatment of PCNSL and can improve the patient’s long-term survival.关键词
原发性非霍奇金淋巴瘤/中枢神经系统/综合治疗Key words
primary non-Hodgkin’s lymphoma/central nervous system/multimodality therapy引用本文复制引用
刘畅,许春伟,张立英,张岩..原发性中枢神经系统非霍奇金淋巴瘤临床分析[J].临床与病理杂志,2016,36(7):909-913,5.
