摘要
Abstract
Objective:To analyze the effects of bisoprolol on cardiac function and N-terminal pro-brain natriuretic peptide (NT-proBNP) level in elderly patients with heart failure.Methods: 240 cases of elderly patients with heart failure in our hospital from April 2013 to April 2015 were randomly divided into observation group and control group, 120 cases for each. They were given angiotensin converting enzyme inhibitors, antiplatelet, statin therapy, etc., the observation group was treated with bisoprolol. hTe clinical effcacy and cardiac function, NT-proBNP, blood pressure and heart rate level in the two groups were compared.Results: hTe total effective rate of the observation group was 86.7%, which was signiifcantly higher than the control group (70.8%), the difference was statistically signiifcant (P<0.05). Atfer treatment, the letf ventricular end-diastolic dimension (LVEDD), letf ventricular end systolic diameter (LVESD), letf ventricular enddiastolic volume (LVEDV), letf ventricular end systolic diameter (LVESV), serum NT-proBNP level of two groups of patients were significantly lower, left ventricular ejection fraction (LVEF) was signiifcantly higher, the change of observation group was more obvious, the difference was statistically signiifcant (P<0.05). hTe heart rate and blood pressure were signiifcantly decreased in the two groups after treatment, and the heart rate of the observation group was more obvious, the difference was statistically significant (P<0.05).Conclusion: The basis of conventional treatment combined with bisoprolol can further reduce the level of serum NT-proBNP in elderly patients with heart failure, which has a positive signiifcance to improve heart function.关键词
比索洛尔/心力衰竭/心功能/N-末端脑钠肽前体Key words
bisoprolol/heart failure/cardiac function/N-terminal pro-brain natriuretic peptide
