河北医学2016，Vol.22Issue(7)：1087-1090,4.DOI:10.3969/j.issn.1006-6233.2016.07.012
右美托咪定对脑功能区肿瘤切除术术中唤醒效果及应激反应的影响
Dexmedetomidine on Intraoperative Stress Reaction and Analepsia in the Resection of Tumors of Cerebral Functional Area
摘要
Abstract
Objective: To evaluate the effects of dexmedetomidine on the intraoperative stress reaction and analepsia in the resection of tumors of cerebral functional area, to provide reference foundations for clini-cal medication for anesthesia. Methods: A total of 50 patients scheduled for intraoperative wake-up test in the resection of tumors of cerebral functional area were randomly divided into observation group and control group, with 25 cases in each group. The observation group was intravenously dripped with a loading dose (1.0μg / kg) of dexmedetomidine at 10min before induction, and then was maintained at 0.2μg•kg-1•h-1; while the con-trol group was given the same dose of 0.9% sodium chloride injection, and the pre-analepsia conditions, times to analepsia, qualities of analepsia, and adverse events in wake-up period were observed, and the plasma lev-els of norepinephrine (NE) and epinephrine (E) on room-entering, at 5min after analepsia, and at the end of the surgery were determined. Results:The patients of the two groups had insignificantly different pre-an-alepsia anesthesia times, blood losses, and urinary volumes (P>0.05); but the observation group had signifi-cantly lower doses of propofol and remifentanil used before analepsia than the control group (P <0.05). The patients of the observation group had significantly shorter time to analepsia and significantly better quality of analepsia than the control group (P <0.05); The incidence of adverse events of the patients of the control group was 44.00%, and was significantly higher than that of the observation group (12.00%) (P<0.05). The patients of the two groups had insignificantly different plasma levels of NE and E on room-entering (P >0. 05); Both groups had significantly increased plasma levels of NE and E at 5min after analepsia and at the end of the surgery compared with those on room-entering, but the control group had significantly greater increasing extents (P<0.05). Conclusion: Use of dexmedetomidine in patients undergoing resection of tumors of cerebral functional area can reduce the dose of narcotics, decrease the plasma concentrations of NE and E, elevate the quality of analepsia, and reduce the incidence of adverse reactions.关键词
脑肿瘤/功能神经外科/右美托咪定/麻醉唤醒试验/应激反应Key words
Brain neoplasm/Functional neurosurgery/Dexmedetomidine/Post - anesthesia wake-up test after anesthesia/Stress reaction引用本文复制引用
刘远春,宋小文,杨红..右美托咪定对脑功能区肿瘤切除术术中唤醒效果及应激反应的影响[J].河北医学,2016,22(7):1087-1090,4.基金项目
泸州市科技计划项目,(编号:2013－S－42－012) （编号:2013－S－42－012）
