河北医学2016，Vol.22Issue(7)：1106-1109,4.DOI:10.3969/j.issn.1006-6233.2016.07.019
两种肌松药不同给药方案对老年肥胖患者的影响
The Effects on Different Administration Regimens of Two Kinds of Muscle Relaxants in Elderly Obese Patients
摘要
Abstract
Objective: To investigate the proper dosage of two kinds of muscle relaxants with different administration regimens in elderly obese patients for short-time surgery. Methods: 60 elder obese patients un-dergoing a short-time surgery after general anesthesia from May 2010 to May 2014 in the Affiliated Hospital of Chengde Medical College were randomized into four groups (n = 15) (body mass index >28 kg / m2 and aged 60-70 yr): Lean body weight group of Atracurium (S1 ); real body weight group of atracurium (S2 ); Lean body weight group of vecuronium ( W1 ); real body weight group of vecuronium ( W2 ). thirty normal body weight patients (BMI 20-24 kg / m2 ) were served as control group(N): Fifteen of atracurium (NS); Fifteen of vecuronium (NW). The onset time, the duration of 25%, the duration of 25 ~ 75%, the duration of 75 ~90% and dose were recorded. Results:The duration of 25%, the duration of 25~75%, and dose are longer in S2 group compared with S1 group and NS group (P<0.05). The duration of 25%, the duration of 25 ~ 75%, and dose are longer in W2 group compared with W1 group and NW group (P<0.05). The duration of 25% and the duration of 25~75% are longer in W1 group compared with S1 group (P<0.05).There are no significant difference in the onset time and the duration of 75~90% among groups. Conclusion: The duration of action of muscle-relaxants are significantly prolonged when the dose is calculated according to real body weight in eldly obese patients. In contrast, when muscle-relaxants are dosed according to the lean body weight in eldly obese patients, the clinical duration of action is shorter and the dose of muscle-relaxants is decreased.关键词
老年肥胖患者/维库溴铵/顺苯磺酸阿曲库铵/净体重Key words
Elderly obese patients/Vecuronium/Atracurium/Lean body weight引用本文复制引用
段凤梅,孙旭颖,李玲..两种肌松药不同给药方案对老年肥胖患者的影响[J].河北医学,2016,22(7):1106-1109,4.基金项目
河北省承德市科学技术研究与发展计划项目,(编号:20157042) （编号:20157042）
