哈尔滨医药2016，Vol.36Issue(3)：201-202,205,3.
BCL-2凋亡基因多态性与潮汕食管鳞癌的关联研究
BCL-2 Gene Polymorphism is Associated With Apoptosis of Esophageal Cancer in Chaoshan
摘要
Abstract
Objective Research on B-cell lymphoma factor 2 gene-938 ( C/A) locus polymorphism and clinical manifestations in patients with esophageal squamous cell carcinoma in Chaoshan, susceptibility and lymph node metastasis risk relationship. Methods Collection of 110 patients with esophageal squamous cell carcinoma in Chaoshan ( January 2012 to December 2014 ) cancer tissue specimens and associated clinical data and 110 specimens of normal esophageal mucosa in healthy people. Used 1:1 paired control re-search method, used aggregate enzyme polymerase chain reaction-restrictive fragment length more state sex analysis (PCR-RFLP) technology, analysis 110 cases esophageal scales cancer patients and the 110 cases as control group of health crowd of BCL-2 gene -938 ( C/A) bit points more state sex;used flow type cell operation and the cell immune fluorescent technology, analysis esophageal scales cancer cells cycle disorder and apoptosis died situation, on BCL-2 protein of expression for quantitative analysis.χ2 test was used to compare different sets of BCL-2 -938 ( C/A) distribution of polymorphic loci genotypic frequencies, and associated clinical stage and lymph node metastases of esophageal squamous cell carcinoma, BCL-2 protein expression and protein tumor pathologic fea-tures of esophageal cancer. Results In esophageal squamous cell carcinoma:analysis of clinical phenotype was associated, AA geno-type frequency was significantly higher in the control group than test Group (P<0. 05). group is stratified by clinical characteristics of different genotypic frequencies distribution after Tip:TNM stage I +II period, the AA genotype frequencies significantly higher than the TNM staging for the phase III + IV (P<0. 05), the difference was statistically significant, showed that with AA genotype of light in the patient's condition without this genotype patients. Conclusion The expression of BCL-2 level and severity of illness in patients with esophageal cancer are related to the contact, and BCL-2 expression associated with a poor prognosis in patients with esophageal cancer.关键词
潮汕食管鳞癌/细胞凋亡/B细胞淋巴瘤因子2/基因多态性Key words
Chaoshan esophageal squamous cell carcinoma/Apoptosis/B-cell lymphoma factor 2 (BCL-2)/Gene polymorphism分类
医药卫生引用本文复制引用
姚铠涛,许惠娟,陈春莉..BCL-2凋亡基因多态性与潮汕食管鳞癌的关联研究[J].哈尔滨医药,2016,36(3):201-202,205,3.基金项目
汕头市医疗科技项目(汕府科[2015]123号) （汕府科[2015]123号）
