哈尔滨医药2016，Vol.36Issue(3)：241-241,242,2.
Toll样受体在胎膜早破新生儿宫内感染中的临床意义
The Eelationship of Premature Rupture of Membranes Toll-Like Receptors in Neonatal Intrauterine Infection
摘要
Abstract
Objective To analysis the relationship of premature rupture of membranes toll-like receptors in neonatal intrauterine infection. Methods Choose 60 cases of premature rupture of membranes >12 h of newborn babies, according to the PCT, CRP, blood routine, blood culture and clinical manifestations of divided into infection and the no infection group. Born in 6 h, 24 h, TLR-2 and TLR-4 mRNA transcription level was evaluated by fluorescence quantitative PCR method, TLR-2 and TLR-4 mRNA expres-sion level was evaluated by flow cytometry instrument line peripheral blood. Results In the infection group, peripheral blood TLR-2 and TLR-4 mRNA at 6 h and 24 h was (5. 45 ± 0. 59), (5. 78 ± 0. 63) and (6. 32 ± 0. 61), (7. 04±0. 38), it is higher than the no infection group, the difference was statistically significant (P<0. 05). Conclusion Premature rupture of membranes in neonatal intrauterine infection, caused by neonatal peripheral blood TLR-2 and TLR-4 mRNA early stage, the marked increase in prompt TLR-2 and TLR-4 mRNA signal pathways in the early neonatal anti-infection immunity.关键词
新生儿/宫内感染/胎膜早破/Toll受体Key words
Newborn baby/Intrauterine infection/Premature rupture of membranes/Toll-like receptor分类
医药卫生引用本文复制引用
颜思璐..Toll样受体在胎膜早破新生儿宫内感染中的临床意义[J].哈尔滨医药,2016,36(3):241-241,242,2.基金项目
广州市医药卫生科技项目(20161A010108) （20161A010108）
