郑州大学学报（医学版）2016，Vol.51Issue(4)：494-497,4.DOI:10.13705/j.issn.1671-6825.2016.04.015
移植物中CCR6＋及CCR7＋T细胞数量与异基因造血干细胞移植受者急性移植物抗宿主病发生的关系
Correlation of quantity of CCR6 + and CCR7 + T lymphocytes in grafts with occurrence of acute graft-versus-host disease in recipients after allo-HSCT
摘要
Abstract
Aim: To detect the quantity of T cell subsets expressing C-C chemokine receptor type 6(CCR6) or CCR7 in the grafts and analyze their correlation with the occurrence of acute graft-versus-host disease(GVHD).Methods: Fifty-two pairs of healthy donor and their recipients with family donor allogenetic hematopoietic stem cell transplantation(allo-HSCT) were included in this study.All the recipients were injected recombinant human granulocyte colony-stimulating factor(rhG-CSF) for mobilizing. The quantity of T cells expressing CCR6 or CCR7 in rhG-CSF mobilized bone marrow grafts(G-BM) and peripheral blood grafts (G-PB) were detected and compared.The correlation of the quantity of each subset cells with the cumulative incidence of gradesⅡto Ⅳ acute GVHD in recipients was analyzed.Results: After rhG-CSF mobilization, G-PB had obviously more T cells than G-BM(P <0.05).CD4+CCR6+, CD8+CCR6+, CD4+CCR7+ and CD8+CCR7+ T cells in G-PB were approximately 15 -25 times more than those in G-BM.And the absolute counts of the above T cell subsets were not risk factors for acute GVHD(P >0.05).Conclusion: The quantity of T cell subsets may not be related to the occurrence of acute GVHD.关键词
急性移植物抗宿主病/CC趋化因子受体6/CC趋化因子受体7/异基因造血干细胞移植Key words
acute graft-versus-host disease/C-C chemokine receptor type 6/C-C chemokine receptor type 7/alloge-netic hematopoietic stem cell transplantation分类
医药卫生引用本文复制引用
王萌,徐衍,孙慧,谢新生,马杰,甘思林,刘延方..移植物中CCR6＋及CCR7＋T细胞数量与异基因造血干细胞移植受者急性移植物抗宿主病发生的关系[J].郑州大学学报（医学版）,2016,51(4):494-497,4.基金项目
国家自然科学基金资助项目 U1504806 （）
