化工进展2016，Vol.35Issue(7)：2109-2112,2113,5.DOI:10.16085/j.issn.1000-6613.2016.07.024
杯芳冠醚的合成及其催化合成对氟硝基苯
Synthesis of calixcrown ethers and its catalytic activity in synthesis of 4-fluoronitrobenzene
摘要
Abstract
Halogen-exchange fluorination is the main method to synthesize fluorinated aromatics. Phase transfer catalysts(PTCs) are essential for the halogen-exchange fluorination. The p-tert-butylcalix[4]-arene- crown-5 was synthesized fromp-tert-butylcalix[4]arene and tetraethylene glycol ditosylate in the presence of K2CO3,and it was used as the phase transfer catalyst in the fluoridation of chlorine nitrobenzene to investigate its performance in the fluorination. The influences of fluorination reaction conditions,such as the reaction time,temperature and different catalysts were investigated. The catalytic activities ofp-tert-butylcalix[4]arene- crown-5 were verified. It was found that the yields of the reaction withp-tert-butylcalix[4]arene-crown-5 as PTC were improved. Catalyzed byp-tert-butylcalix[4]arene-crown-5 for 3 h,the reaction had a conversion of 96.53% and the yield of 4-fluoronitrobenzene was 90.8%.关键词
有机化合物/卤素交换氟化/催化Key words
organic compounds/halogen exchange fluorination/catalysis分类
化学工程引用本文复制引用
李成龙,徐珍,吕早生,严若康,刘秋鸽,吴洋..杯芳冠醚的合成及其催化合成对氟硝基苯[J].化工进展,2016,35(7):2109-2112,2113,5.基金项目
2014年湖北省大学生创新创业训练计划项目（201410488033）。 （）
