化工进展2016，Vol.35Issue(7)：2151-2155,5.DOI:10.16085/j.issn.1000-6613.2016.07.031
载5-氟尿嘧啶壳聚糖/明胶微粒的制备及药物释放性能
Preparation of 5-fluorouracil loaded chitosan/gelatin particles and its’ drug release properties
摘要
Abstract
Chitosan and Gelatin are good biocompatible polymers and are suitble for drug carriers. Preparation of 5-fluorouracil loaded chitosan/gelatin particles andin vitro release were performed using emulsion crosslinking method with paraffin oil as external phase and chitosan/gelatin as internal phase, andthe optimal formulations were verified by orthogonal design. The drug loading,encapsulation efficiency,the microscopic morphology and release behavior ofdrug loaded particlesin vitrowere examined.The optimal preparation conditions were:the ratio of water to oil 1∶7,the ratio of chitosan/gelatin concentration 1∶3,emulsifying time 5min,emulsifying temperature 60℃, glutaraldehyde dosage 5.5mmol/L,reaction time 1h,and emulsifier dosage 100.7mmol/L. Under these conditions,the drug loading of particles was 34.96% and encapsulation efficiency was 38.36%. Infrared spectroscopy showed that chitosan/gelatin microparticles have loaded 5-Fu. Microparticles were spherical with smooth surface.5-Fu can be encapsuoed inchitosan/gelatin by emulsion crosslinking method. This method was simple and reproducible and drug release performancein vitro showed that the microparticles had obviously sustained release effect.关键词
制备/优化设计/载体/壳聚糖/明胶/5-氟尿嘧啶/体外释药Key words
preparation/optimal design/support/chitosan/gelatin/5- fluorouracil/in vitro drug release分类
化学化工引用本文复制引用
贺宝元,张宝艳,李珊,薛海燕..载5-氟尿嘧啶壳聚糖/明胶微粒的制备及药物释放性能[J].化工进展,2016,35(7):2151-2155,5.基金项目
国家自然科学基金（31301405）、陕西省科技统筹计划（2013KTZB02-02-05(2)）、西安市科技计划（CXY1434(4)）及陕西省教育厅专项（16JK1088）项目。 （2）
