摘要
Abstract
Objective To observe and analyze the relationship between the etiological classification and the plasma homo‐cysteine(Hcy)level in ischemic cerebral stroke(ICS)patients.Methods 180 cases with ICS were selected as the study group and were grouped according to the TOAST etiological classification.The patients with large artery atherosclerosis-type stroke (LAA subtype)were divided into the intracranial lesion group ,the extra-cranial lesion group and the intracranial and extra-cra‐nial lesion group according to the atherosclerotic lesion sites.60 healthy people were selected as the control group.The levels of plasma Hcy ,the triglyceride(TG) ,the total cholesterol(TC) ,the high density lipoprotein(HDL) ,the low density lipoprotein (LDL) ,the blood glucose(BG) ,the systolic blood pressure(SBP) ,the diastolic blood pressure(DBP)of all the included objects were detected and compared.Results The level of plasma Hcy of the study group was significantly higher than that of the con‐trol group(t=4.627 ,P<0.05) ,which was only positively correlated with the age of the included objects(standardized regres‐sion coefficient= 0.386 ,t= 3.862 ,P< 0.05 ).In addition ,the smoking history (OR= 9.134 ) ,the drinking history (OR=1.387) ,the high blood pressure disease(OR=11.687) ,the level of TC(OR=1.517) ,the level of LDL(OR=2.998) ,the level of Hcy(OR=1.156)were positively correlated with the pathogenesis of ICS(P<0.05);The level of plasma Hcy in LAA group was significantly higher than that of other groups(q=3.628~5.126 ,P<0.05) ,which was significantly higher in extracranial lesion group compared with that in the intracranial lesion group or the intracranial and extracranial lesion group(q=5.155 , 4.827 ,P<0.05).Conclusions The increase of the plasma Hcy level is the independent risk factors for ICS ,which especially has a close correlation with the occurrence of LAA subtype and the extracranial arterial lesion ,while has nothing to do with the other traditional factors.The clinicians should take timely and appropriate intervention measures according to the level of plas‐ma Hcy of the patients .关键词
缺血性脑卒中/病因学分型/同型半胱氨酸/相关性分析Key words
Ischemic cerebral stroke/Etiological classification/Homocysteine/Correlation analysis分类
医药卫生
