中国实用神经疾病杂志2016，Vol.19Issue(15)：15-17,3.
急性白血病患儿伴中枢神经系统并发症临床特点及危险因素分析
Analysis of clinical features and risk factors of children with acute leukemia complicated with central nervous system complications
王毅捷 1马亚震 2孙和顺3
作者信息
- 1. 河北廊坊市经济技术开发区人民医院 廊坊 065000
- 2. 河北大城县中医院 大城 065900
- 3. 河北廊坊市第三人民医院 廊坊 065000
- 折叠
摘要
Abstract
Objective To analyze the clinical features and risk factors of children with acute leukemia (AL) complicated with central nervous system (CNS) complications .Methods Seventy children with acute leukemia admitted into our hospital from March 2010 to March 2015 were selected as the research objects .The clinical data of all children were retrospectively an-alyzed ,including the occurrence rate of CNS complications and their clinical features and the risk factors of CNS complications were analyzed at the same time .Results There were 12 cases (17 .14% ) of CNS in 70 cases ,including 8 cases of AML com-plicated with CNS ,3 cases of ALL complicated with CNS and 1 case of acute granular lymphocyte leukemia and the complica-tions of CNS mainly were intracranial hemorrhage .The occurrence rates of CNS complications with platelet counts less than 50 × 109 L - 1 (whether or not) were 50 .00% and 2 .08% .The rates of white blood cell counts more than 100 × 109 L - 1 (whether or not) respectively were 50 .00% and 2 .08% .The rate of lymphadenectasis(whether or not) respectively was 47 .62% and 4 . 08% and there was significant difference between the two groups(P < 0 .01) .Logistic regression analysis showed that less than 50 × 109 L - 1 of the platelet counts ,more than 100 × 109 L - 1 of white blood cell counts and lymphadenectasis were the risk factors of AL with CNS complications .Conclusion Intracranial hemorrhage is common in children with acute leukemia com-plicated with central nervous system complications .And the risk factors affecting the occurrence of CNS complications include low platelet count ,high white blood cell count and lymphadenectasis .关键词
急性白血病/中枢神经系统/并发症/危险因素Key words
Acute leukemia/Central nervous system/Complications/Risk factors分类
医药卫生引用本文复制引用
王毅捷,马亚震,孙和顺..急性白血病患儿伴中枢神经系统并发症临床特点及危险因素分析[J].中国实用神经疾病杂志,2016,19(15):15-17,3.
