湖南中医药大学学报2016，Vol.36Issue(8)：26-29,81,5.DOI:10.3969/j.issn.1674-070X.2016.08.007
白子菜提取物对急性痛风性关节炎大鼠模型抗炎作用的研究
Anti-inflammatory Effect of Gynura divaricata (Linn.) DC. Extract on Rat Models with Acute Gouty Arthriti
刘昌盛 1陈昉 1何颖 1李桂元 1姚红 1童娟1
作者信息
- 1. 广州医科大学附属第一医院，广东 广州 510120
- 折叠
摘要
Abstract
Objective To explore the anti-inflammatory of Gynura divaricata (Linn.) DC. extract on rat models with acute gouty arthritis. Methods Seventy-two Wistar rats were randomly divided into nine groups (eight rats in each group):blank group, model group, colchicines group, ethanol extract of G. divaricata groups (high-dose group, middle-dose group and low-dose group), water extract of G. divaricata Groups (high-dose group, middle-dose group, low-dose group). After 5 h of modeling, the rats were given medicine continously. After 7 d of treatment, the inflammatory cells among joint tissue and the concentrations of IL-1β, TNF-α from serum were observed and determined. Results The foot inflammation condition of G. divaricata extract groups (high-dose and middle-dose) and colchicines group were significantly lower than that of model group (P<0.05). The lymphocytes, neutrophils among joint tissue in the medicine intervention groups were significantly lower than that of model group (P<0.05) and there were no significantly difference between each of the two medicine intervention groups (P>0.05). The expression of TNF-α in the colchicines group was significantly lower than that in the model group (P<0.05). The expression of IL-1β in G. divaricata ethanol-extract groups and colchicines group were significantly lower than that of model group (P<0.05). Conclusion Colchicines and G. divaricata ethanol-extract group of middle-dose show significant anti-inflammatory effect on rat models with acute gouty arthritis.关键词
白子菜提取物/急性痛风性关节炎/抗炎免疫作用Key words
Gynura divaricata (Linn.) DC. extract/acute gouty arthritis/anti-inflammatory and immunity effect分类
医药卫生引用本文复制引用
刘昌盛,陈昉,何颖,李桂元,姚红,童娟..白子菜提取物对急性痛风性关节炎大鼠模型抗炎作用的研究[J].湖南中医药大学学报,2016,36(8):26-29,81,5.
