湖南中医药大学学报2016，Vol.36Issue(9)：13-15,56,4.DOI:10.3969/j.issn.1674-070X.2016.09.003
基于PCA-GRA的补阳还五汤及其精简方抗脑缺血损伤功效的谱效关系研究
The Spectrum-Effect Relationship of Buyang Huanwu and its Optimized Prescriptions on Cebebral Ischemia Injury Based on PCA-GRA Method
摘要
Abstract
The HPLC fingerprint of the 12 batches of Buyang Huanwu Decoction and the 14 batches of its optimized prescriptions were determined. The principal component analysis (PCA) was used to reduce the data dimension. The ranked first batch of fingerprints of Chinese medicines were evaluated. The protective effects of brain damage and the characteristic peaks were correlated by grey relational analysis (GRA). The correlation between common peaks and charactersistic peaks of Buyang Huanwu Decoction and its optimized prescriptions with its contribution onthe protective effect of cebebral ischemia were discussed. According to the method of PCA and GRA, the spectrum-effect relationship research of Buyang Huanwu Decoction can be improved effectively and accurately.关键词
补阳还五汤/谱效关系/主成分分析/灰色关联度/脑缺血损伤Key words
Buyang Huanwu Decoction/spectrum-effect relationship/PCA/GRA/cebebral ischemia injury分类
医药卫生引用本文复制引用
刘青萍,晏峻峰,杨欣,夏相宜,张水寒,刘芳,王宇红,蔡光先..基于PCA-GRA的补阳还五汤及其精简方抗脑缺血损伤功效的谱效关系研究[J].湖南中医药大学学报,2016,36(9):13-15,56,4.基金项目
国家重点基础研究发展计划（973计划）课题（2012CB723503）；湖南省教育厅科技项目（13C683，13C672）；湖南省教育厅（KC2011B027）；湖南省中药粉体与创新药物省部共建国家重点实验室培育基地开放基金(2013年)；中医药数字化技术基础研究平台。 （2013年）
