湖南中医药大学学报2016，Vol.36Issue(9)：16-20,5.DOI:10.3969/j.issn.1674-070X.2016.09.004
枳壳对丁螺环酮在健康大鼠体内药物动力学的影响
Effects of Fructus aurantii on Pharmacokinetics of Buspirone in Healthy Rats
摘要
Abstract
Objective To investigate the effect of Fructus aurantii on the pharmacokinetics of buspirone in healthy rats. Methods SD rats were randomly divided into buspirone group, the low dose group of Fructus aurantii (15 g/kg) plus buspirone, and the high dose group of Fructus aurantii (30 g/kg) plus buspirone, respectively. The blood concentrations of buspirone were determined after 5, 10, 20, 30, 45, 60, 90, 120, 240, 360, 480, 600 min and their pharmacokinetic parameters were calculated. Results Compared with the buspirone group, the AUC(0-t) of the low dose group and high dose group were increased by 2.49 and 4.18 time and the Cmax were increased by 1.63 and 2.57 time, respectively. The Tmax of the low dose group and high dose group were extended from 0.28 h to 0.52 h and 1.06 h and the t1/2 were extended from 0.96 h to 2.18 h and 4.87 h, respectively. The differences were statistically significant (P<0.05). Conclusion Fructus aurantii can increase the AUC(0-t) and Cmax of buspirone, improve the bioavailability of buspirone, and the changs of parameters show the dependence trendency. Fructus aurantii and buspirone have significant pharmacokinetic interactions.关键词
枳壳/丁螺环酮/药物动力学/药动学相互作用Key words
Fructus aurantii/buspirone/pharmacokinetics/pharmacokinetic interactions分类
医药卫生引用本文复制引用
姚佳梅,邱新建,黄惠勇,赵琳琳,王文波,周露,王胜,陈琼,胡随瑜..枳壳对丁螺环酮在健康大鼠体内药物动力学的影响[J].湖南中医药大学学报,2016,36(9):16-20,5.基金项目
国家中医药管理局全国名老中医药专家胡随瑜传承工作室建设项目(国中医药人教发[2014]20号)；国家自然科学基金青年基金资助项目（81202807）；中国博士后科学基金第57批面上资助项目（2015M572254）。 （国中医药人教发[2014]20号）
