湖南中医药大学学报2016，Vol.36Issue(9)：26-28,3.DOI:10.3969/j.issn.1674-070X.2016.09.006
清热解毒化浊片对ETM兔肝组织CD14及TNF-α、IL-1表达的影响
Effect of Qingre Jiedu Huazhuo Tablets on Expression of CD14 in Liver Tissue, TNF-α and IL-1 of ETM Rabbits
摘要
Abstract
Objective To investigate the effect of Qingre Jiedu Huazhuo (QJH) tablets on the expression of CD14, TNF-α and IL-1 in liver tissue of ETM rabbits. Methods The 21 New Zealand big-eared rabbits were randomly divided into normal group, model group, QJH tablets group, 7 in each group. The ear edge of model group and QJH group was given intravenous injection of 10 μg/kg endotoxin. After 2 hours of modeling, the rabbites were given intervention. Then, the liver function, TNF-α and IL-1 were tested. The CD14 in liver tissue was determined and the pathological morphology was observed. Results (1) Compared with the model group, the ALT and AST of QJH tablets group were increased (P<0.05). The CD14 expression in liver tissue and serum TNF-α and IL-1 were decreased (P<0.05). (2) The liver cell array structure of model group was disorder with inflammatory cells infiltration and a cavity change, but the changes in QJH tablets group and blank group were not obvious. Conclusion Qingre Jiedu Huazhuo tablets with multi-point target and munti-effects can decrease CDl4, TNF-α and IL-1 in ETN rabbits, suggesting the tablets have an effect on the signaling pathway induced by LPS in the early days.关键词
内毒素血症/清热解毒化浊片/CD14/肿瘤坏死因子-α/白细胞介素-1/茵陈/黄芩/滑石Key words
endotoxemia/Qingre Jiedu Huazhuo tablets/CD14/TNF-a/IL-1/oriental wormwood/radix scutellariae/talc分类
医药卫生引用本文复制引用
赵国荣,尹周安,张衎,何宜荣,艾碧琛,肖碧跃,贺又舜,左亚杰,熊焰,陈兰玲..清热解毒化浊片对ETM兔肝组织CD14及TNF-α、IL-1表达的影响[J].湖南中医药大学学报,2016,36(9):26-28,3.基金项目
湖南省教育厅重点项目资助（12A101）；湖南中医药大学中医临床基础重点学科资助 （）
湖南中医药大学校级青年基金（校行科字[2013]4号）资助。 （）
