华西口腔医学杂志2016，Vol.34Issue(4)：404-407,4.DOI:10.7518/hxkq.2016.04.017
涎腺腺样囊性癌中BNIP3蛋白的表达及临床意义分析
Analysis of BNIP3 expression and clinical research in salivary adenoid cystic carcinoma
摘要
Abstract
ObjectiveThis study investigated the expression of BNIP3 in salivary adenoid cystic carcinoma (SACC) and its correlations to the clinicopathological features and prognosis of patients with SACC. The role of BNIP3 in the progress of hypoxia-induced autophagy was elucidated.Methods The expression levels of BNIP3, hypoxia inducible factor (HIF)-1α, and LC3 in 65 SACC cases were detected by immunohistochemical staining method, and the correlation between the expres-sion of BNIP3 and the clinicopathological features in SACC was analyzed. In addition, the correlations of BNIP3 gene expres-sion with HIF-1α and LC3 gene expression were analyzed. The survival rate of patients with SACC was evaluated by univa-riate survival analysis.Results BNIP3 was considerably expressed in SACC in all three histological patterns, and was positive in 41 cases (63.1%). BNIP3 gene expression was significantly correlated with histological grade (P=0.001) and HIF-1α gene expression (P=0.011). By contrast, BNIP3 gene expression was not significantly correlated with LC3 gene expression (P=0.167). The overall survival rate of patients with negative BNIP3 expression was better than that of patients with positive BNIP3 expression (P<0.05).Conclusion BNIP3 might play a vital role in the tumorigenesis of SACC and may be a new target for gene therapy.关键词
腺样囊性癌/BNIP3蛋白/低氧/低氧诱导因子/自噬Key words
adenoid cystic carcinoma/BNIP3/hypoxia/hypoxia inducible factor/autophagy分类
医药卫生引用本文复制引用
陈占伟,孙杜斌,黄圣运,吴海威,张东升..涎腺腺样囊性癌中BNIP3蛋白的表达及临床意义分析[J].华西口腔医学杂志,2016,34(4):404-407,4.基金项目
山东省自然科学基金 （）
